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Toliprolol

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names：
1-(Isopropylamino)-3-(m-tolyloxy)-2-propanol
CAS號(hào)：
2933-94-0
MDL Number：
MF(分子式)： C13H21NO2 MW(分子量)： 223.32
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	1-(Isopropylamino)-3-(m-tolyloxy)-2-propanol
英文別名	Toliprolol; Toliprololum; MHIP;
CAS號(hào)	2933-94-0
Inchi	InChI=1S/C13H21NO2/c1-10(2)14-8-12(15)9-16-13-6-4-5-11(3)7-13/h4-7,10,12,14-15H,8-9H2,1-3H3
InchiKey	NXQMNKUGGYNLBY-UHFFFAOYSA-N
分子式 Formula	C13H21NO2
分子量 Molecular Weight	223.32
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	Toliprolol(CAS:2933-94-0):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	Toliprolol is an adrenergic receptor antagonist with some stimulant action; it has been proposed for angina pectoris.
Application1
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危險(xiǎn)性	Warning
危險(xiǎn)性警示
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[1]Gane P, Stroesco V, Granici A. [Research on the relation between beta-adrenergic blockade with propranolol of toliprolol and the central effects of nialamide]. Physiologie. 1977 Jan-Mar;14(1):21-5. French. PubMed PMID: 16302.

[2]Vierling W, Gorbahn H, Ammon HP, Estler CJ. [Effect of ethanol and toliprolol on the carbohydrate metabolism of the brain and liver]. Arzneimittelforschung. 1980;30(5):773-6. German. PubMed PMID: 6104970.

[3] Wuppermann D, Zimmermann F, Friedrich L. [Comparative study on the effects of alprenolol, bunitrolol, ethaverine, oxprenolol, papaverine, practolol, pindolol, pronethalol, propranolol, toliprolol and verapamil on cardiac and bronchial beta-receptors (author's transl)]. Arzneimittelforschung. 1978;28(5):794-8. German. PubMed PMID: 35172.

[4] Doze P, Elsinga PH, Maas B, Van Waarde A, Wegman T, Vaalburg W. Synthesis and evaluation of radiolabeled antagonists for imaging of beta-adrenoceptors in the brain with PET. Neurochem Int. 2002 Feb;40(2):145-55. PubMed PMID: 11738481.

[5] Gogaladze K, Chankvetadze L, Tsintsadze M, Farkas T, Chankvetadze B. Effect of basic and acidic additives on the separation of some basic drug enantiomers on polysaccharide-based chiral columns with acetonitrile as mobile phase. Chirality. 2015 Mar;27(3):228-34. doi: 10.1002/chir.22417. Epub 2015 Jan 6. PubMed PMID: 25564994.

6: Sada H, Ban T. Frequency-dependent block of nerve conduction by beta-adrenergic blocking agents. Arch Int Pharmacodyn Ther. 1981 Nov;254(1):134-44. PubMed PMID: 6121535.7: White JD, Shaw S. A new catalyst for the asymmetric Henry reaction: synthesis of β-nitroethanols in high enantiomeric excess. Org Lett. 2012 Dec 21;14(24):6270-3. doi: 10.1021/ol3030023. Epub 2012 Nov 30. PubMed PMID: 23194499.8: Bartsch W, Dietmann K, Leinert H, Sponer G. Cardiac action of carazolol and methypranol in comparison with other beta-receptor blockers. Arzneimittelforschung. 1977;27(5):1022-6. PubMed PMID: 18157.9: Breier C, Kain H, Konzett H. The variance of forearm blood flow as an indicator of emotional stress. Eur J Clin Pharmacol. 1983;25(4):535-8. PubMed PMID: 6228433.10: Marmol F, Puig-Parellada P, Forn J. Interactions of lithium with the adrenergic system in electrically-stimulated guinea pig myenteric plexus isolated preparations. Actions of a phosphodiesterase inhibitor. Methods Find Exp Clin Pharmacol. 1992 Oct;14(8):623-8. PubMed PMID: 1283616.1

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