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S119-8

NMR下載 COA and HPLC MSDS下載
names：
S119-8
CAS號：
443639-96-1
MDL Number： MFCD01121291
MF(分子式)： C23H24N2O MW(分子量)： 344.45
EINECS: Reaxys Number:
Pubchem ID:1787280 Brand:BIOFOUNT

S119-8(443639-96-1)是A型和B型流感病毒的廣譜抑制劑。

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數(shù)量	總計 (￥)
YZM000736-10mg	10mg	99.49%	￥ 2430.00	￥ 2430.00		2-3天	- +	￥ 0.00
YZM000736-5mg	5mg	99.49%	￥ 1462.50	￥ 1462.50		2-3天	- +	￥ 0.00

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中文別名	S119-8(443639-96-1);N-（4-苯胺基苯基）-4-叔丁基苯甲酰胺;4-（叔丁基）-N-（4-（苯基氨基）苯基）苯甲酰胺;
英文別名	S119-8(443639-96-1);N-(4-anilinophenyl)-4-tert-butylbenzamide;4-(tert-Butyl)-N-(4-(phenylamino)phenyl)benzamide;
CAS號	443639-96-1
Inchi	InChI = 1S / C23H24N2O / c1-23（2,3）18-11-9-17（10-12-18）22（26）25-21-15-13-20（14-16-21）24- 19-7-5-4-6-8-19 / h4-16,24H，1-3H3，（H，25,26）
InchiKey	NEPKMQDGCTXOPG-UHFFFAOYSA-N
分子式 Formula	C23H24N2O
分子量 Molecular Weight	344.45
溶解度Solubility	生物體外In Vitro:DMSO溶解度≥ 150 mg/mL(435.48 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性狀	白色至米色粉末 ,Power
儲藏條件 Storage conditions	2-8°C,-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

S119-8(443639-96-1)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags:S119-8試劑,S119-8雜質(zhì),S119-8中間體,S119-8密度,S119-8合成,S119-8溶解度,S119-8旋光度,S119-8閃點,S119-8購買,S119-8MSDS,

產(chǎn)品說明	S119-8(443639-96-1)是A型和B型流感病毒的廣譜抑制劑。
Introduction	S119-8(443639-96-1)is a broad spectrum inhibitor of influenza AandB viruses.
Application1
Application2
Application3

S119-8(443639-96-1)藥理學：

1、S119-8(443639-96-1)是A型和B型流感病毒的廣譜抑制劑。

2、S119-8是S119的類似物。S119-8獲得了增強的廣譜活性，具有改進的計算物理性能，同時保持了顯著的效能（IC₅₀= 1.43μM）（無毒（CC）₅₀= 66.10μM）濃度，盡管它比針對流感A / WSN / 33 H1N1（WSN）病毒的親本S119濃度要高（7倍）。S119-8還顯示出對多種乙型流感病毒和耐奧司他韋的甲型流感病毒的活性，但不抑制非流感病毒水皰性口炎（VSV）。S119-8增強了對甲型和乙型流感病毒的抑制廣度，但效力卻僅有很小的損失。S119-8通過IC抑制流感病毒A /波多黎各/ 8/1934（H1N1）（PR8）₅₀為6.05μM。S119-8通過IC抑制甲型流感/越南/ 1203/2004（H5N1）₅₀ 為8.42μM。

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

White KM, et al. Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. ACS Infect Dis. 2018 Feb 9;4(2):146-157.

S119-8(443639-96-1)參考文獻：

1、Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein
Kris M White 1, Pablo Abreu Jr 1, Hui Wang, Paul D De Jesus, Balaji Manicassamy 1, Adolfo García-Sastre 1, Sumit K Chanda, Robert J DeVita, Megan L Shaw

Abstract S119 was a top hit from an ultrahigh throughput screen performed to identify novel inhibitors of influenza virus replication. It showed a potent antiviral effect (50% inhibitory concentration, IC50 = 20 nM) and no detectable cytotoxicity (50% cytotoxic concentration, CC50 > 500 μM) to yield a selectivity index greater than 25 000. Upon investigation, we found that S119 selected for resistant viruses carrying mutations in the viral nucleoprotein (NP). These resistance mutations highlight a likely S119 binding site overlapping with but not identical to that found for the compound nucleozin. Mechanism of action studies revealed that S119 affects both the oligomerization state and cellular localization of the NP protein which has an impact on viral transcription, replication, and protein expression. Through a hit-to-lead structure-activity relationship (SAR) study, we found an analog of S119, named S119-8, which had increased breadth of inhibition against influenza A and B viruses accompanied by only a small loss in potency. Finally, in vitro viral inhibition assays showed a synergistic relationship between S119-8 and oseltamivir when they were combined, indicating the potential for future drug cocktails.

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