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Guanfu base H

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names：
Guanfu base H
CAS號(hào)：
4758-99-0
MDL Number：
MF(分子式)： C22H34ClNO2 MW(分子量)： 379.96
EINECS: Reaxys Number:
Pubchem ID:73388 Brand:BIOFOUNT

Guanfu base H(4758-99-0)是從Aconitum coreanum中分離出的一種二萜生物堿，對(duì)惡性瘧原蟲具有很強(qiáng)的抗瘧原蟲活性，對(duì)惡性瘧原蟲 TM4/8.2 菌株 (野生型) 和 K1CB1 菌株 IC₅₀ 值分別為 4 μM 和 3.6 μM。

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫(kù)存描述	數(shù)量	總計(jì) (￥)
YZM000830-500mg	500mg	>95%	￥ 0.00	￥ 0.00		Backorder	- +	￥ 0.00
YZM000830-100mg	100mg	>95%	￥ 0.00	￥ 0.00		Backorder	- +	￥ 0.00

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中文別名	Guanfu base H(4758-99-0);Atisinium chloride;Atisine hydochloride
英文別名	Guanfu base H,4758-99-0
CAS號(hào)	4758-99-0
Inchi	InChI=1S/C22H34NO2/c1-15-16-4-8-21(19(15)25)9-5-17-20(2)6-3-7-22(17,18(21)12-16)14-23(13-20)10-11-24/h14,16-19,24-25H,1,3-13H2,2H3/q+1
InchiKey	RXGJFLXLQIECAN-UHFFFAOYSA-N
分子式 Formula	C22H34ClNO2
分子量 Molecular Weight	379.96
溶解度Solubility
性狀	Solid
儲(chǔ)藏條件 Storage conditions	存放在陰涼干燥處，短期（數(shù)天至數(shù)周）在0-4℃，長(zhǎng)期（數(shù)月至數(shù)年）在-20℃。

Guanfu base H(4758-99-0)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲(chǔ)，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染

Guanfu base H(4758-99-0) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產(chǎn)品說明	Guanfu base H(4758-99-0)是從Aconitum coreanum中分離出的一種二萜生物堿，對(duì)惡性瘧原蟲具有很強(qiáng)的抗瘧原蟲活性
Introduction	Guanfu base H (4758-99-0) is a diterpene alkaloid isolated from Aconitum coreanum, which has strong anti-plasmodium activity against Plasmodium falciparum
Application1
Application2
Application3

警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對(duì)身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過程中防止吸入、食入，做好安全防護(hù)

Antifeedant C20 diterpene alkaloids PMID 17191910; Chemistry & biodiversity 2004 Sep; 1(9):1327-35

Alkaloids from Delphinium staphisagria PMID 10978212; Journal of natural products 2000 Aug; 63(8):1136-9

Diterpenoid alkaloid derivatives as potential chemotherapeutic agents in American trypanosomiasis PMID 16391494; Pharmacology 2006; 76(3):123-8

Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum PMID 20561926; Journal of ethnopharmacology 2010 Aug; 130(3):559-62

WU Qiong, et al. Simultaneous Determination of Guanfu Base A,Guanfu Base I and Guanfu Base H in Radix Aconitum coreanum(Lévl) Rapaics by RP-HPLC. Progress in Pharmaceutical Sciences. 2011, 35(5), 230-

Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum
Ethnopharmacological relevance: The plant Aconitum orochryseum Stapf. (Ranunculaceae) is employed together with other plants in Bhutanese traditional medicine and is indicated for malaria-associated fever.
Aim of the study: To study the in vitro antiplasmodial activity of atisinium chloride, the major alkaloid from Aconitum orochryseum.
Materials and methods: Atisinium chloride was extracted and purified from aerial parts of Aconitum orochryseum and its structure and absolute configuration confirmed by single crystal X-ray crystallography. The crude methanol extract, crude alkaloid fraction, and atisinium chloride were tested for in vitro antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (TM4; wild type) and K1CB1 (K1; chloroquine and antifolate resistant).
Results: The diterpenoid alkaloid atisinium chloride was shown to have moderate antiplasmodial activities with IC(50) values of 4 microM and 3.6 microM, respectively against the TM4 strain and the K1 strain of Plasmodium falciparum.
Conclusions: Our studies provide the first evidence in support of one of the indicated treatments with Aconitum orochryseum in Bhutanese traditional medicine. This alkaloid also represents a potential new antimalarial structural lead.

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