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Isochondrodendrine

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names：
Isochondrodendrine
CAS號(hào)：
477-62-3
MDL Number： MFCD01734108
MF(分子式)： C36H38N2O6 MW(分子量)： 594.7
EINECS: Reaxys Number:
Pubchem ID:197726 Brand:BIOFOUNT

Isochondrodendrine(477-62-3)是異喹啉和雙芐基異喹啉生物堿的成員。

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫存描述	數(shù)量	總計(jì) (￥)
YZM000835-5mg	5mg	>95%	￥ 0.00	￥ 0.00		Backorder	- +	￥ 0.00
YZM000835-1mg	1mg	>95%	￥ 0.00	￥ 0.00		Backorder	- +	￥ 0.00

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中文別名	Isochondrodendrine(477-62-3);異粒枝堿;羥基箭毒堿
英文別名	Isochondrodendrine,477-62-3;Isobebeerine;Isobebeerin
CAS號(hào)	477-62-3
Inchi	InChI=1S/C36H38N2O6/c1-37-15-13-23-19-29(41-3)33(39)35-31(23)27(37)17-21-5-9-26(10-6-21)44-36-32-24(20-30(42-4)34(36)40)14-16-38(2)28(32)18-22-7-11-25(43-35)12-8-22/h5-12,19-20,27-28,39-40H,13-18H2,1-4H3
InchiKey	XIOGHHPVBVXQIV-UHFFFAOYSA-N
分子式 Formula	C36H38N2O6
分子量 Molecular Weight	594.7
溶解度Solubility
性狀	Solid
儲(chǔ)藏條件 Storage conditions	存放在陰涼干燥處，短期（數(shù)天至數(shù)周）在0-4℃，長期（數(shù)月至數(shù)年）在-20℃。

Isochondrodendrine(477-62-3)毒性測試：

生物	測試類型	路線	報(bào)告劑量（標(biāo)準(zhǔn)化劑量）	影響	參考
mouse	LD50	intraperitoneal	1001 mg/kg (1001 mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX); LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Annales Pharmaceutiques Francaises., 7(569), 1949 [PMID:15401074]
mouse	LD50	subcutaneous	371 mg/kg (371 mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX); LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Annales Pharmaceutiques Francaises., 7(569), 1949 [PMID:15401074]

Isochondrodendrine(477-62-3)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲(chǔ)，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染

Isochondrodendrine(477-62-3) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:Isochondrodendrine(477-62-3),Isochondrodendrine試劑,Isochondrodendrine的純度,Isochondrodendrine的雜質(zhì),Isochondrodendrine的外觀,Isochondrodendrine的合成,Isochondrodendrine的MSDS,Isochondrodendrine的廠家,Isochondrodendrine的價(jià)格

產(chǎn)品說明	Isochondrodendrine(477-62-3)是一類從Isolona ghesquiereina中分離出來的雙芐基異喹啉生物堿
Introduction	Isochondrodendrine(477-62-3) is a class of bisbenzylisoquinoline alkaloid isolated fromIsolona ghesquiereina.
Application1	Isochondodendrine has strong antiplasmodial activity againstPlasmodium falciparum.
Application2
Application3

警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過程中防止吸入、食入，做好安全防護(hù)

Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum PMID 15996841; Journal of ethnopharmacology 2005 Oct; 102(1):89-94

[Alkaloids of African Menispermaceae, Epinetrum cordifolium and Epinetrum mangenotii: isolation of cycleanine, norcycleanine and isochondrodendrine] PMID 5955797; Annales pharmaceutiques francaises 19

[Two novel bisbenzylisoquinoline alkaloids from Cyclea sutchuenensis Gagnep] PMID 8285068; Yao xue xue bao = Acta pharmaceutica Sinica 1993; 28(8):599-603

Spectral characterisation and antiplasmodial activity of bisbenzylisoquinolines from Isolona ghesquiereina PMID 10985080; Planta medica 2000 Aug; 66(6):537-40

New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia PMID 22230193; Fitoterapia 2012 Apr; 83(3):476-80

Spectral characterisation and antiplasmodial activity of bisbenzylisoquinolines from Isolona ghesquiereina
Abstract:From stem barks of Isolona guesquiereina three known bisbenzylisoquinolines were isolated and identified as (-)-curine, chondrofoline and isochondodendrine. Structures were established mainly on the basis of comparison of their physical and spectral data with published data for them and their methylated derivatives. Cleavage with sodium in liquid ammonia was necessary to unambiguously determine the stereochemistry of (-)-curine and subsequently establish its stereochemical link with chondrofoline, erroneously assigned as 7-O-methyl-(+)-curine. Complete and unambiguous 1H-, 15N- and 13C-NMR assignments of the three alkaloids were made by means of 2D-NMR techniques namely, COSY, HMQC, gs-HMQC, HMBC and NOESY. (-)-Curine, isochondrodendrine and their methylated derivatives were shown to exhibit strong in vitro antiplasmodial activity and in vivo activity was also observed for (-)-curine.

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