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RSV604 racemate

NMR下載 COA and HPLC MSDS下載
names：
RSV604 racemate
CAS號(hào)：
676128-62-4
MDL Number： NA
MF(分子式)： C22H17FN4O2 MW(分子量)： 388.39
EINECS:No data available Reaxys Number:No data available
Pubchem ID:5279171 Brand:BIOFOUNT

RSV604 racemate(676128-62-4) 是一種外消旋混合物，與S-異構(gòu)體相比，RSV604 racemate 對(duì)呼吸道合胞病毒(RSV)菌株的作用效果弱很多。

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫(kù)存描述	數(shù)量	總計(jì) (￥)
YZM000873-10mg	10mg	98%	￥ 2430.00	￥ 2430.00		2-3天	- +	￥ 0.00
YZM000873-5mg	5mg	98%	￥ 1462.00	￥ 1462.00		2-3天	- +	￥ 0.00

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中文別名	RSV604 racemate(676128-62-4);RSV604 R enantiomer;;RSV604 (racemate)
英文別名	RSV604 racemate(676128-62-4);RSV604 R enantiomer;;RSV604 (racemate)
CAS號(hào)	676128-62-4
Inchi	InChI=1S/C22H17FN4O2/c23-16-11-5-7-13-18(16)25-22(29)27-20-21(28)24-17-12-6-4-10-15(17)19(26-20)14-8-2-1-3-9-14/h1-13,20H,(H,24,28)(H2,25,27,29)
InchiKey	MTPVBMVUENFFLL-UHFFFAOYSA-N
分子式 Formula	C22H17FN4O2
分子量 Molecular Weight	388.39
溶解度Solubility	生物體外In Vitro:DMSO溶解度50 mg/mL(128.74 mM;Need ultrasonic)H2O< 0.1 mg/mL(insoluble)
性狀	白色至灰白色固體粉末
儲(chǔ)藏條件 Storage conditions	在-20°C條件下保存3年,在4°C條件下保存2年

RSV604 racemate(676128-62-4)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲(chǔ)，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染

RSV604 racemate(676128-62-4) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:RSV604 racemate(676128-62-4),RSV604 racemate抑制劑,RSV604 racemate的純度,RSV604 racemate試劑,RSV604 racemate的外觀,RSV604 racemate的用途,RSV604 racemate的合成,RSV604 racemate的生產(chǎn),RSV604 racemate的溶解度

產(chǎn)品說明	RSV604 racemate(676128-62-4) 與S-異構(gòu)體相比，對(duì)呼吸道合胞病毒(RSV)菌株的作用效果弱很多。
Introduction	RSV604 racemate(676128-62-4) is a racemic mixture, shows less potency against strains of respiratory syncytial virus (RSV) than the Ssomer.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對(duì)身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過程中防止吸入、食入，做好安全防護(hù)

New strategies for control of respiratory syncytial virus infection

1,4-benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate.

1,4-benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate.
Abstract:Respiratory syncytial virus (RSV) is the cause of one-fifth of all lower respiratory tract infections worldwide and is increasingly being recognized as representing a serious threat to patient groups with poorly functioning or immature immune systems. Racemic 1,4-benzodiazepines show potent anti-RSV activity in vitro. Anti-RSV evaluation of 3-position R- and S-benzodiazepine enantiomers and subsequent optimization of this series resulted in selection of a clinical candidate. Antiviral activity was found to reside mainly in the S-enantiomer, and the R-enantiomers were consistently less active against RSV. Analogues of 1,4-(S)-benzodiazepine were synthesized as part of the lead optimization program at Arrow and tested in the XTT assay. From this exercise, (S)-1-(2-fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)-urea, 17b (RSV-604) was identified as a clinical candidate, exhibiting potent anti-RSV activity in the XTT assay, which was confirmed in secondary assays. Compound 17b also possessed a good pharmacokinetic profile and has now progressed into the clinic.

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MSDS

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SDS 1.0 英文

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