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Alfadolone acetate

NMR下載 COA and HPLC MSDS下載
names：
2-((3R,5S,8S,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-11-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
CAS號：
23930-37-2
MDL Number：
MF(分子式)： C23H34O5 MW(分子量)： 390.52
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Alfadolone acetate
英文別名	Alfadolone acetate; GR-2; GR 2; GR2; 1574; R-140; R140; R 140; V-140; V 140; V140; alphadolone acetate
CAS號	23930-37-2
Inchi	InChI=1S/C23H34O5/c1-13(24)28-12-20(27)18-7-6-17-16-5-4-14-10-15(25)8-9-22(14,2)21(16)19(26)11-23(17,18)3/h14-18,21,25H,4-12H2,1-3H3/t14-,15+,16-,17-,18+,21+,22-,23-/m0/s1
InchiKey	QRJOQYLXZPQQMX-FWROMSNXSA-N
分子式 Formula	C23H34O5
分子量 Molecular Weight	390.52
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Alfadolone acetate(CAS:23930-37-2):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Alfadolone acetate (also known as GR-2, 1574, R-140, V-140, and alphadolone acetate) is a gamma-aminobutyric acid (GABA) receptor agonist potentially for the treatment of cancer related pain.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
安全防護(hù)
備注

[1]Nadeson R, Goodchild CS. Antinociceptive properties of neurosteroids III: experiments with alphadolone given intravenously, intraperitoneally, and intragastrically. Br J Anaesth. 2001 May;86(5):704-8. PubMed PMID: 11575348.

[2]Nadeson R, Goodchild CS. Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors. Pain. 2000 Oct;88(1):31-9. PubMed PMID: 11098097.

[3] Benoit E. Effects of intravenous anaesthetics on nerve axons. Eur J Anaesthesiol. 1995 Jan;12(1):59-70. PubMed PMID: 7705328.

[4] Nádvorník P, Kolarík J, Drlicková V. Contribution of pregnan steroid Althesin to the pathophysiology of epilepsy. Acta Univ Palacki Olomuc Fac Med. 1990;128:17-21. PubMed PMID: 2149796.

[5] Brown JN, Thorne PR, Nuttall AL. Blood pressure and other physiological responses in awake and anesthetized guinea pigs. Lab Anim Sci. 1989 Mar;39(2):142-8. PubMed PMID: 2709804.

6: Cervantes M, Ruelas R, Sánchez R, Alvarez-Reséndiz G. Brain injury following cardiorespiratory arrest in cats. Effects of alphaxalone-alphadolone. Bol Estud Med Biol. 1989 Jan-Jun;37(1-2):17-27. PubMed PMID: 2803470.7: Benoit E, Carratù MR, Mitolo-Chieppa D. Mechanism of action of a structural analog of alphaxalone on myelinated nerve fibre. Eur J Pharmacol. 1988 Dec 6;158(1-2):1-9. PubMed PMID: 2851452.8: Suzuki T, Tomioka M, Uchida MK. Inhibitory effects of steroidal anesthetics on histamine release from rat mast cells stimulated by concanavalin A, compound 48/80 and A23187. Gen Pharmacol. 1988;19(3):435-40. PubMed PMID: 2458297.9: Emanuele MA, Tentler J, Kirsteins L, Reda D, Emanuele NV, Lawrence AM. Anaesthesia with alphaxalone plus alphadolone acetate decreases serum concentrations of LH in castrated rats. J Endocrinol. 1987 Nov;115(2):221-3. PubMed PMID: 3437247.10: Perrot D, Pugeat M, Bonneton A, Mounier-Kuhn A, Motin J, Forest MG. Althesin interaction with human plasma steroid binding globulins. Eur J Clin Pharmacol. 1985;29(2):181-5. PubMed PMID: 4076318.1

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