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Aprikalim

NMR下載 COA and HPLC MSDS下載
names：
2H-Thiopyran-2-carbothioamide, tetrahydro-N-methyl-2-(3-pyridinyl)-, 1-oxide, (1R-trans)-
CAS號：
132562-26-6
MDL Number：
MF(分子式)： C12H16N2O2S2 MW(分子量)： 284.39
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Aprikalim
英文別名	RP 49356; RP-49356; RP49356; Aprikalim; RP 52891; RP-52891; RP-52891;
CAS號	132562-26-6
Inchi	InChI=1S/C12H16N2OS2/c1-13-11(16)12(6-2-3-8-17(12)15)10-5-4-7-14-9-10/h4-5,7,9H,2-3,6,8H2,1H3,(H,13,16)/t12-,17-/m1/s1
InchiKey	GKEMHVLBZNVZOI-SJKOYZFVSA-N
分子式 Formula	C12H16N2O2S2
分子量 Molecular Weight	284.39
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Aprikalim(CAS:132562-26-6):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Aprikalim is a potent, specific, and selective opener of ATP-sensitive K+ (KATP) channels. Aprikalim affords cardioprotection and at higher doses also causes peripheral or coronary vasodilatation.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Lozos VA, Toumpoulis IK, Agrogiannis G, Giamarellos-Bourboulis EJ, Chamogeorgakis TP, Rizos IK, Patsouris ES, Anagnostopoulos CE, Rokkas CK. Aprikalim a potassium adenosine triphosphate channel opener reduces neurologic injury in a rabbit model of spinal cord ischemia. Int J Surg. 2013;11(4):354-9. doi: 10.1016/j.ijsu.2013.02.025. Epub 2013 Mar 5. PubMed PMID: 23473993.

[2]He GW, Yang CQ. Inhibition of vasoconstriction by potassium channel opener aprikalim in human conduit arteries used as bypass grafts. Br J Clin Pharmacol. 1997 Oct;44(4):353-9. PubMed PMID: 9354310; PubMed Central PMCID: PMC2042851.

[3] Pignac J, Lacaille C, Dumont L. Protective effects of the K+ ATP channel opener, aprikalim, against free radicals in isolated rabbit hearts. Free Radic Biol Med. 1996;20(3):383-9. PubMed PMID: 8720909.

[4] Belin V, Hodge T, Picaut P, Jordan R, Algate C, Gosselin S, Nohynek G, Cavero I. The myocardial lesions produced by the potassium channel opener aprikalim in monkeys and rats are prevented by blockade of cardiac beta-adrenoceptors. Fundam Appl Toxicol. 1996 Jun;31(2):259-67. PubMed PMID: 8789792.

[5] Li HY, Wu S, He GW, Wong TM. Aprikalim reduces the Na+-Ca2+ exchange outward current enhanced by hyperkalemia in rat ventricular myocytes. Ann Thorac Surg. 2002 Apr;73(4):1253-9; discussion 1259-60. PubMed PMID: 11996269.

6: Liu MH, Floten HS, Furnary AP, Yim AP, He GW. Effects of potassium channel opener aprikalim on the receptor-mediated vasoconstriction in the human internal mammary artery. Ann Thorac Surg. 2001 Feb;71(2):636-41. PubMed PMID: 11235720.7: Bastin R, Albadri H, Gaumont AC, Gulea M. Pyridinedithioesters as heterodienophiles: application to the synthesis of aprikalim. Org Lett. 2006 Mar 16;8(6):1033-6. PubMed PMID: 16524261.8: Thuringer D, Cavero I, Coraboeuf E. Time-dependent fading of the activation of KATP channels, induced by aprikalim and nucleotides, in excised membrane patches from cardiac myocytes. Br J Pharmacol. 1995 May;115(1):117-27. PubMed PMID: 7647966; PubMed Central PMCID: PMC1908735.9: Ibbotson T, Edwards G, Noack T, Weston AH. Effects of P1060 and aprikalim on whole-cell currents in rat portal vein; inhibition by glibenclamide and phentolamine. Br J Pharmacol. 1993 Apr;108(4):991-8. PubMed PMID: 8485637; PubMed Central PMCID: PMC1908130.10: Pignac J, Bourgouin J, Dumont L. Cold cardioplegia and the K+ channel modulator aprikalim (RP 52891): improved cardioprotection in isolated ischemic rabbit hearts. Can J Physiol Pharmacol. 1994 Feb;72(2):126-32. PubMed PMID: 8050052.1

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