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Aptiganel

NMR下載 COA and HPLC MSDS下載
names：
1-(3-ethylphenyl)-1-methyl-3-(naphthalen-1-yl)guanidine
CAS號(hào)：
137159-92-3
MDL Number：
MF(分子式)： C20H21N3 MW(分子量)： 303.409
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Aptiganel
英文別名	CNS-1102; CNS 1102; CNS1102; Aptiganel; Cerestat.
CAS號(hào)	137159-92-3
Inchi	InChI=1S/C20H21N3/c1-3-15-8-6-11-17(14-15)23(2)20(21)22-19-13-7-10-16-9-4-5-12-18(16)19/h4-14H,3H2,1-2H3,(H2,21,22)
InchiKey	BFNCJMURTMZBTE-UHFFFAOYSA-N
分子式 Formula	C20H21N3
分子量 Molecular Weight	303.409
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Aptiganel(CAS:137159-92-3):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Aptiganel, also known as CNS-1102, and Cerestat; was a drug candidate that acted as a noncompetitive NMDA antagonist and that was under development by Cambridge Neuroscience, Inc as a treatment for stroke. It has neuroprotective effects and was researched for potential use in the treatment of stroke, but despite positive results in animal studies, human trials showed limited efficacy.
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危險(xiǎn)性	Warning
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[1]Albers GW, Goldstein LB, Hall D, Lesko LM; Aptiganel Acute Stroke Investigators. Aptiganel hydrochloride in acute ischemic stroke: a randomized controlled trial. JAMA. 2001 Dec 5;286(21):2673-82. PubMed PMID: 11730442.

[2]Dyker AG, Edwards KR, Fayad PB, Hormes JT, Lees KR. Safety and tolerability study of aptiganel hydrochloride in patients with an acute ischemic stroke. Stroke. 1999 Oct;30(10):2038-42. PubMed PMID: 10512904.

[3] Kroppenstedt SN, Schneider GH, Thomale UW, Unterberg AW. Neuroprotective properties of aptiganel HCL (Cerestat) following controlled cortical impact injury. Acta Neurochir Suppl. 1998;71:114-6. PubMed PMID: 9779160.

[4] Kroppenstedt SN, Schneider GH, Thomale UW, Unterberg AW. Protective effects of aptiganel HCl (Cerestat) following controlled cortical impact injury in the rat. J Neurotrauma. 1998 Mar;15(3):191-7. PubMed PMID: 9528919.

[5] Bokesch PM, Halpin DP, Ranger WR, Drummond-Webb JJ, Marchand JE, Bronson RT, Warner KG, Kream RM. Immediate-early gene expression in ovine brain after hypothermic circulatory arrest: effects of aptiganel. Ann Thorac Surg. 1997 Oct;64(4):1082-7; discussion 1088. PubMed PMID: 9354532.

6: Muir KW, Grosset DG, Lees KR. Effects of prolonged infusions of the NMDA antagonist aptiganel hydrochloride (CNS 1102) in normal volunteers. Clin Neuropharmacol. 1997 Aug;20(4):311-21. PubMed PMID: 9260729.7: McBurney RN. Development of the NMDA ion-channel blocker, aptiganel hydrochloride, as a neuroprotective agent for acute CNS injury. Int Rev Neurobiol. 1997;40:173-95. Review. PubMed PMID: 8989621.

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