購物車 
-
Calactin
- names：
Card-20(22)-enolide, 3-((4,6-dideoxy-beta-D-erythro-hexopyranos-2-ulos-1-yl)oxy)-2,14-dihydroxy-19-oxo-, (2alpha,3beta,5alpha)-
- CAS號：
20304-47-6
MDL Number： - MF(分子式)： C29H40O10 MW(分子量)： 548.629
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價格 (￥) | 現(xiàn)價(￥) | 特價(￥) | 庫存描述 | 數(shù)量 | 總計 (￥) |
|---|
| 中文別名 | Calactin |
| 英文別名 | Calactin; Pecilocerin B; Pekilocerin B; Poekilocerin B; Pokilocerin B |
| CAS號 | 20304-47-6 |
| Inchi | InChI=1S/C29H40O10/c1-15-9-21(31)25(34)29(36,38-15)39-23-11-17-3-4-20-19(27(17,14-30)12-22(23)32)5-7-26(2)18(6-8-28(20,26)35)16-10-24(33)37-13-16/h10,14-15,17-23,31-32,35-36H,3-9,11-13H2,1-2H3/t15-,17+,18-,19+,20-,21+,22-,23-,26-,27-,28+,29+/m1/s1 |
| InchiKey | WLEPWZGEVXFKPT-FFLRHQAWSA-N |
| 分子式 Formula | C29H40O10 |
| 分子量 Molecular Weight | 548.629 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產(chǎn)品說明 | Calactin(CAS:20304-47-6):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。 |
| Introduction | Calactin comes from the roots of the Asclepias curassavica L. and has anticancer properties from inducing apoptosis through an ERK signaling pathway. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Lee CC, Lin YH, Chang WH, Wu YC, Chang JG. The small molecule calactin induces DNA damage and apoptosis in human leukemia cells. Eur J Cancer Prev. 2012 Sep;21(5):467-73. PubMed PMID: 22828439. |
| [2]Parsons JA, Summers RJ. Cat assay for the emetic action of digitalis and related glycosides (digitoxin, digoxin, lanatoside C, ouabain and calactin). Br J Pharmacol. 1971 May;42(1):143-52. PubMed PMID: 5580699; PubMed Central PMCID: PMC1666988. |
| [3] Liu J, Bai LP, Yang F, Yao X, Lei K, Kei Lam CW, Wu Q, Zhuang Y, Xiao R, Liao K, Kuok H, Li T, Liu L. Potent Antagonists of RORγt, Cardenolides from Calotropis gigantea, Exhibit Discrepant Effects on the Differentiation of T Lymphocyte Subsets. Mol Pharm. 2019 Feb 4;16(2):798-807. doi: 10.1021/acs.molpharmaceut.8b01063. Epub 2019 Jan 22. PubMed PMID: 30592425. |
| [4] Mebs D, Wunder C, Toennes SW. Poor sequestration of toxic host plant cardenolides and their rapid loss in the milkweed butterfly Danaus chrysippus (Lepidoptera: Nymphalidae: Danainae: Danaini). Toxicon. 2017 Jun 1;131:1-5. doi: 10.1016/j.toxicon.2017.03.006. Epub 2017 Mar 9. PubMed PMID: 28284846. |
| [5] Mutlib AE, Cheung HT, Watson TR. In vitro metabolism of the cardiotonic steroids gomphogenin and calactin. J Steroid Biochem. 1988 Jan;29(1):135-43. PubMed PMID: 3347047. |
6: Groeneveld HW, Steijl H, Van Den Berg B, Elings JC. Rapid, quantitative HPLC analysis ofAsclepias fruticosa L. andDanaus plexippus L. cardenolides. J Chem Ecol. 1990 Dec;16(12):3373-82. doi: 10.1007/BF00982104. PubMed PMID: 24263435.7: Mohamed NH, Liu M, Abdel-Mageed WM, Alwahibi LH, Dai H, Ismail MA, Badr G, Quinn RJ, Liu X, Zhang L, Shoreit AA. Cytotoxic cardenolides from the latex of Calotropis procera. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4615-20. doi: 10.1016/j.bmcl.2015.08.044. Epub 2015 Aug 21. PubMed PMID: 26323871.8: Züst T, Petschenka G, Hastings AP, Agrawal AA. Toxicity of Milkweed Leaves and Latex: Chromatographic Quantification Versus Biological Activity of Cardenolides in 16 Asclepias Species. J Chem Ecol. 2019 Jan;45(1):50-60. doi: 10.1007/s10886-018-1040-3. Epub 2018 Dec 7. PubMed PMID: 30523520.9: Hamed AI, Plaza A, Balestrieri ML, Mahalel UA, Springuel IV, Oleszek W, Pizza C, Piacente S. Cardenolide glycosides from Pergularia tomentosa and their proapoptotic activity in Kaposi's sarcoma cells. J Nat Prod. 2006 Sep;69(9):1319-22. PubMed PMID: 16989527.10: Brower LP, Seiber JN, Nelson CJ, Lynch SP, Hoggard MP, Cohen JA. Plant-determined variation in cardenolide content and thin-layer chromatography profiles of monarch butterflies,Danaus plexippus reared on milkweed plants in California : 3. Asclepias californica. J Chem Ecol. 1984 Dec;10(12):1823-57. doi: 10.1007/BF00987364. PubMed PMID: 24318436.1
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