購物車 
-
Fostedil
- names：
diethyl (4-(benzo[d]thiazol-2-yl)benzyl)phosphonate
- CAS號：
75889-62-2
MDL Number： - MF(分子式)： C18H20NO3PS MW(分子量)： 361.3958
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價格 (￥) | 現價(￥) | 特價(￥) | 庫存描述 | 數量 | 總計 (￥) |
|---|
| 中文別名 | Fostedil |
| 英文別名 | KB-944; KB 944; KB944; A 53986; A-53986; BRN 3626546; Fostedil |
| CAS號 | 75889-62-2 |
| Inchi | InChI=1S/C18H20NO3PS/c1-3-21-23(20,22-4-2)13-14-9-11-15(12-10-14)18-19-16-7-5-6-8-17(16)24-18/h5-12H,3-4,13H2,1-2H3 |
| InchiKey | FVYRUSCZCWSFLT-UHFFFAOYSA-N |
| 分子式 Formula | C18H20NO3PS |
| 分子量 Molecular Weight | 361.3958 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產品說明 | Fostedil(CAS:75889-62-2):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。 |
| Introduction | Fostedil, also known as KB-944, is a calcium channel antagonist potentially for the treatment of angina pectoris. KB-944 increased regional segment function in normal and ischemic regions and maintained distal coronary artery perfusion pressure, coronary flow and transmural regional myocardial blood flow during partial coronary artery occlusion despite a reduction in aortic pressure. In a model of total coronary artery occlusion. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Sekine Y, Hirakawa N, Kashiwaba N, Matsumoto H, Kutsuma T, Yamaura T, Sekine A. A novel histamine 2(H2) receptor antagonist with gastroprotective activity. I. Synthesis and pharmacological evaluation of N-phenoxypropylacetamide derivatives with thioether function. Chem Pharm Bull (Tokyo). 1998 Apr;46(4):610-5. PubMed PMID: 9579036. |
| [2]Tchani G, Baziard-Mouysset G, Stigliani JL, Payard M, Bonnafous R, Tisne-Versailles J. Influence of the vinyl group on the calcium antagonistic activity of analogues of Fostedil. Pharm Acta Helv. 1994 Jan;68(3):173-9. PubMed PMID: 8121926. |
| [3] Rose U. [2-Aryl substituted benzo-anellated 5-ring-heterocycles as potential agents for the cardiovascular system. 2. 1,3-Benzimidazoles]. Pharmazie. 1991 Nov;46(11):775-7. German. PubMed PMID: 1811227. |
| [4] Staudinger R, Knaus HG, Glossmann H. Positive heterotropic allosteric regulators of dihydropyridine binding increase the Ca2+ affinity of the L-type Ca2+ channel. Stereoselective reversal by the novel Ca2+ antagonist BM 20.1140. J Biol Chem. 1991 Jun 15;266(17):10787-95. PubMed PMID: 1645709. |
| [5] Mouysset G, de Saqui-Sannes G, Younes S, Bellan J, Payard M, Tisne-Versailles J. Contribution of the diethyl phosphonate group to a first approach of calcium-inhibiting activity: study of a series of various substituted 2-phenylbenzothiazoles. Farmaco. 1990 Sep;45(9):945-52. PubMed PMID: 2282126. |
6: Yoshino K, Goto K, Yoshiizumi K, Morita T, Tsukamoto G. Organic phosphorus compounds. 5. (4-Benzothiazol-2-ylbenzyl)amidophosphonate as potent calcium antagonistic vasodilators. J Med Chem. 1990 Aug;33(8):2192-6. PubMed PMID: 2374146.7: Yoshino K, Goto K, Kohno T, Morita T, Tsukamoto G. Organic phosphorus compounds. IV. Asymmetric 4-(benzothiazol-2-yl)benzylphosphonates as potent calcium antagonistic vasodilators. Chem Pharm Bull (Tokyo). 1990 Mar;38(3):676-80. PubMed PMID: 2347009.8: Bellucci C, Gualtieri F, Scapecchi S, Teodori E, Budriesi R, Chiarini A. Negative inotropic and calcium antagonistic activity of alkyl and arylalkyl phosphonates. Farmaco. 1989 Dec;44(12):1167-91. PubMed PMID: 2634406.9: Yoshino K, Kohno T, Morita T, Tsukamoto G. Organic phosphorus compounds. 2. Synthesis and coronary vasodilator activity of (benzothiazolylbenzyl) phosphonate derivatives. J Med Chem. 1989 Jul;32(7):1528-32. PubMed PMID: 2738888.10: Chiarini A, Valenti P, Fabbri G, da Re P. Chromosome and xanthone derivatives related to Fostedil. Acta Pharm Suec. 1987;24(5):257-62. PubMed PMID: 3450191.1
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