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Iobenguane

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names：
2-[(3-iodophenyl)methyl]guanidine
CAS號：
139755-80-9
MDL Number：
MF(分子式)： C8H10IN3 MW(分子量)： 275.0896
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Iobenguane
英文別名	Iobenguane, Adreview, Metaiodobenzylguanidine
CAS號	139755-80-9
Inchi	InChI=1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)
InchiKey	PDWUPXJEEYOOTR-UHFFFAOYSA-N
分子式 Formula	C8H10IN3
分子量 Molecular Weight	275.0896
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Iobenguane(CAS:139755-80-9):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Iobenguane is a radiopharmaceutical, used in a scintigraphy method called MIBG scan. Iobenguane is a radiolabeled molecule similar to noradrenaline. It localizes to adrenergic tissue and thus can be used to identify the location of tumors such as phaeochromocytomas and neuroblastomas. With I-131 it can also be used to eradicate tumor cells that take up and metabolize norepinephrine.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
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備注

[1]Feola M, Chauvie S, Biggi A, Testa M. Role of (123)I-Iobenguane Myocardial Scintigraphy in Predicting Short-term Left Ventricular Functional Recovery: An Interesting Image. J Clin Imaging Sci. 2015 Oct 30;

5:56. doi: 10.4103/2156-7514.168707. eCollection 2015. PubMed PMID: 26664773; PubMed Central PMCID: PMC4647125.

[3]Chin BB, Kronauge JF, Femia FJ, Chen J, Maresca KP, Hillier S, Petry NA, James OG, Oldan JD, Armor T, Stubbs JB, Stabin MG, Babich JW. Phase-1 clinical trial results of high-specific-activity carrier-free 123I-iobenguane. J Nucl Med. 2014 May;55(5):765-71. doi: 10.2967/jnumed.113.124057. Epub 2014 Mar 13. PubMed PMID: 24627436.

[4]Coleman RE, Stubbs JB, Barrett JA, de la Guardia M, Lafrance N, Babich JW. Radiation dosimetry, pharmacokinetics, and safety of ultratrace Iobenguane I-131 in patients with malignant pheochromocytoma/paraganglioma or metastatic carcinoid. Cancer Biother Radiopharm. 2009 Aug;24(4):469-75. doi: 10.1089/cbr.2008.0584. PubMed PMID: 19694582.

[5] Cortés-Blanco A, Martínez Lázaro R, Vargas Castrillón E. [Authorized specifications for human use in clinical practice of radiopharmaceuticals composed of iobenguane (123I) marketed in Spain]. Rev Esp Med Nucl. 2008 Nov-Dec;27(6):468-74. Spanish. PubMed PMID: 19094909.

5: Hinkle GH, Dura JV, Morosco RS, Nahata MC. Extended stability of iobenguane under simulated clinical conditions. Am J Health Syst Pharm. 2008 Jan 15;65(2):142-4. doi: 10.2146/ajhp070247. PubMed PMID: 18192259.

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