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JM-221

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names：
Platinum, amminebis(butanoato-O)dichloro(cyclohexanamine)-, (OC-6-43)-
CAS號：
129551-91-3
MDL Number：
MF(分子式)： C14H30Cl2N2O4Pt MW(分子量)： 556.39
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	JM-221
英文別名	JM-221, JM 221, JM221
CAS號	129551-91-3
Inchi	1S/C6H13N.2C4H8O2.2ClH.H3N.Pt/c7-6-4-2-1-3-5-6;21-2-3-4(5)6;;;;/h6H,1-5,7H2;22-3H2,1H3,(H,5,6);2*1H;1H3;/q;;;;;;+4/p-4
InchiKey	XMOWMXXEICQRQH-UHFFFAOYSA-J
分子式 Formula	C14H30Cl2N2O4Pt
分子量 Molecular Weight	556.39
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	JM-221(CAS:129551-91-3):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	JM-221 is a novel platinum(IV) dicarboxylate complex exhibiting enhanced cytotoxicity in human ovarian carcinoma cell line when compared to Cisplatin. Comparison with platinum accumulation from Cisplatin suggests that the increased cytotoxicity of JM-221 may be related to increased accumulation within the cell. JM-221 is more lipophilic than Cisplatin, which may account for improved uptake in Cisplatin resistant cells.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Orr RM, O'Neill CF, Nicolson MC, Barnard CF, Murrer BA, Giandomenico CM, Vollano JF, Harrap KR. Evaluation of novel ammine/amine platinum (IV) dicarboxylates in L1210 murine leukaemia cells sensitive and resistant to cisplatin, tetraplatin or carboplatin. Br J Cancer. 1994 Sep;70(3):415-20. PubMed PMID: 8080724; PubMed Central PMCID: PMC2033379.

[2]McKeage MJ, Abel G, Kelland LR, Harrap KR. Mechanism of action of an orally administered platinum complex [ammine bis butyrato cyclohexylamine dichloroplatinum (IV) (JM221)] in intrinsically cisplatin-resistant human ovarian carcinoma in vitro. Br J Cancer. 1994 Jan;69(1):1-7. PubMed PMID: 8286188; PubMed Central PMCID: PMC1968778.

[3] Mellish KJ, Kelland LR, Harrap KR. In vitro platinum drug chemosensitivity of human cervical squamous cell carcinoma cell lines with intrinsic and acquired resistance to cisplatin. Br J Cancer. 1993 Aug;68(2):240-50. PubMed PMID: 8347478; PubMed Central PMCID: PMC1968570.

[4] Kelland LR, Murrer BA, Abel G, Giandomenico CM, Mistry P, Harrap KR. Ammine/amine platinum(IV) dicarboxylates: a novel class of platinum complex exhibiting selective cytotoxicity to intrinsically cisplatin-resistant human ovarian carcinoma cell lines. Cancer Res. 1992 Feb 15;52(4):822-8. PubMed PMID: 1737343.

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