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Lixazinone sulfate

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names：
N-cyclohexyl-N-methyl-4-((2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxy)butanamide sulfate hydrate
CAS號：
101626-67-9
MDL Number：
MF(分子式)： C21H32N4O8S MW(分子量)： 500.56
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Lixazinone sulfate
英文別名	Lixazinone sulfate; RS-82856; RS 82856; RS82856;
CAS號	101626-67-9
Inchi	InChI=1S/C21H28N4O3.H2O4S.H2O/c1-24(16-6-3-2-4-7-16)20(27)8-5-11-28-17-9-10-18-15(12-17)13-25-14-19(26)23-21(25)22-18;1-5(2,3)4;/h9-10,12,16H,2-8,11,13-14H2,1H3,(H,22,23,26);(H2,1,2,3,4);1H2
InchiKey	IXJGUUXNDBSBPT-UHFFFAOYSA-N
分子式 Formula	C21H32N4O8S
分子量 Molecular Weight	500.56
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Lixazinone sulfate(CAS:101626-67-9):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Lixazinone sulfate is a cyclic AMP phosphodiesterase (cAMP PDE) inhibitor and cardiotonic agent.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
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備注

[1]Cheng J, Thompson MA, Walker HJ, Gray CE, Warner GM, Zhou W, Grande JP. Lixazinone stimulates mitogenesis of Madin-Darby canine kidney cells. Exp Biol Med (Maywood). 2006 Mar;231(3):288-95. PubMed PMID: 16514175.

[2]Venuti MC, Alvarez R, Bruno JJ, Strosberg AM, Gu L, Chiang HS, Massey IJ, Chu N, Fried JH. Inhibitors of cyclic AMP phosphodiesterase. 4. Synthesis and evaluation of potential prodrugs of lixazinone (N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2- oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide, RS-82856). J Med Chem. 1988 Nov;31(11):2145-52. PubMed PMID: 2846840.

[3] Venuti MC, Stephenson RA, Alvarez R, Bruno JJ, Strosberg AM. Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline. J Med Chem. 1988 Nov;31(11):2136-45. PubMed PMID: 2846839.

[4] Kenan Y, Murata T, Shakur Y, Degerman E, Manganiello VC. Functions of the N-terminal region of cyclic nucleotide phosphodiesterase 3 (PDE 3) isoforms. J Biol Chem. 2000 Apr 21;275(16):12331-8. PubMed PMID: 10766874.

[5] Dickinson NT, Jang EK, Haslam RJ. Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits cAMP accumulation in human platelets: effects on platelet aggregation. Biochem J. 1997 Apr 15;323 ( Pt 2):371-7. PubMed PMID: 9163326; PubMed Central PMCID: PMC1218329.

6: Matousovic K, Tsuboi Y, Walker H, Grande JP, Dousa TP. Inhibitors of cyclic nucleotide phosphodiesterase isozymes block renal tubular cell proliferation induced by folic acid. J Lab Clin Med. 1997 Nov;130(5):487-95. PubMed PMID: 9390636.7: Dousa TP. Signaling role of PDE isozymes in pathobiology of glomerular mesangial cells. Studies in vitro and in vivo. Cell Biochem Biophys. 1998;29(1-2):19-34. PubMed PMID: 9631236.8: Chini CC, Grande JP, Chini EN, Dousa TP. Compartmentalization of cAMP signaling in mesangial cells by phosphodiesterase isozymes PDE3 and PDE4. Regulation of superoxidation and mitogenesis. J Biol Chem. 1997 Apr 11;272(15):9854-9. PubMed PMID: 9092521.9: Tang KM, Jang EK, Haslam RJ. Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur J Pharmacol. 1994 Jun 15;268(1):105-14. PubMed PMID: 7925608.10: Tsuboi Y, Shankland SJ, Grande JP, Walker HJ, Johnson RJ, Dousa TP. Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV. J Clin Invest. 1996 Jul 15;98(2):262-70. PubMed PMID: 8755633; PubMed Central PMCID: PMC507426.1

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