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Lombricine

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names：
O-((2-guanidinoethoxy)(hydroxy)phosphoryl)-L-serine
CAS號：
18416-85-8
MDL Number：
MF(分子式)： C6H15N4O6P MW(分子量)： 270.18
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Lombricine
英文別名	Lombricine; L-Lombricine;
CAS號	18416-85-8
Inchi	InChI=1S/C6H15N4O6P/c7-4(5(11)12)3-16-17(13,14)15-2-1-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H,13,14)(H4,8,9,10)/t4-/m0/s1
InchiKey	GSDBGCKBBJVPNC-BYPYZUCNSA-N
分子式 Formula	C6H15N4O6P
分子量 Molecular Weight	270.18
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Lombricine(CAS:18416-85-8):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Lombricine is a phosphagen that is unique to earthworms. Structurally, it is a phosphodiester of 2-guanidinoethanol and D-serine.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Doumen C. Variable intron/exon structure in the oligochaete lombricine kinase gene. Gene. 2012 Sep 1;505(2):276-82. doi: 10.1016/j.gene.2012.06.007. Epub 2012 Jun 12. PubMed PMID: 22705027.

[2]Bush DJ, Kirillova O, Clark SA, Davulcu O, Fabiola F, Xie Q, Somasundaram T, Ellington WR, Chapman MS. The structure of lombricine kinase: implications for phosphagen kinase conformational changes. J Biol Chem. 2011 Mar 18;286(11):9338-50. doi: 10.1074/jbc.M110.202796. Epub 2011 Jan 6. PubMed PMID: 21212263; PubMed Central PMCID: PMC3058953.

[3] Nagasawa H, Sawaki K, Fujii Y, Kobayashi M, Segawa T, Suzuki R, Inatomi H. Inhibition by lombricine from earthworm (Lumbricus terrestris) of the growth of spontaneous mammary tumours in SHN mice. Anticancer Res. 1991 May-Jun;11(3):1061-4. PubMed PMID: 1909513.

[4] Ellington WR, Bush J. Cloning and expression of a lombricine kinase from an echiuroid worm: insights into structural correlates of substrate specificity. Biochem Biophys Res Commun. 2002 Mar 8;291(4):939-44. PubMed PMID: 11866456.

[5] Doumen C. cDNA identification, comparison and phylogenetic aspects of lombricine kinase from two oligochaete species. Comp Biochem Physiol B Biochem Mol Biol. 2010 Jun;156(2):137-43. doi: 10.1016/j.cbpb.2010.03.002. Epub 2010 Mar 15. PubMed PMID: 20230902.

6: BEATTY IM, MAGRATH DI, ENNOR AH. Occurrence of D-serine in lombricine. Nature. 1959 Feb 28;183(4661):591. PubMed PMID: 13632801.7: ROSENBERG H, ROSSITER RJ, GAFFNEY T, ENNOR AH. Lombricine phosphoryltransferase in earthworms. Biochim Biophys Acta. 1960 Jan 15;37:385-6. PubMed PMID: 14438944.8: BEATTY IM, ENNOR AH, ROSENBERG H, MAGRATH DI. The configuration of the serine moiety of lombricine and reptilian serine ethanolamine phosphodiester. J Biol Chem. 1961 Apr;23

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