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Prajmalium

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names：
Ajmalanium, 17,21-dihydroxy-4-propyl-, (17R,21-alpha)-
CAS號(hào)：
35080-11-6
MDL Number：
MF(分子式)： C23H33N2O2 MW(分子量)： 369.53
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Ajmalanium, 17,21-dihydroxy-4-propyl-, (17R,21-alpha)-
英文別名	Prajmalum
CAS號(hào)	35080-11-6
Inchi	InChI=1S/C23H33N2O2/c1-4-10-25-17-11-14(13(5-2)22(25)27)19-18(25)12-23(21(19)26)15-8-6-7-9-16(15)24(3)20(17)23/h6-9,13-14,17-22,26-27H,4-5,10-12H2,1-3H3/q+1/t13-,14-,17-,18-,19-,20-,21+,22+,23+,25-/m0/s1
InchiKey	UAUHEPXILIZYCU-ALHOSYKFSA-N
分子式 Formula	C23H33N2O2
分子量 Molecular Weight	369.53
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	Prajmalium(CAS:35080-11-6):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類(lèi)或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	Prajmalium is a derivative of the rauwolfia alkaloid AJMALINE. It is an anti-arrhythmia agent, but may cause liver damage.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
安全防護(hù)
備注

[1]Piekarska A. [Cholestatic hepatitis caused by prajmalium treatment: case report]. Pol Arch Med Wewn. 2003 Jun;109(6):629-32. Polish. PubMed PMID: 14567096.

[2]Fischer S, Reinhold S, Kettner W. [Brugada syndrome]. Med Klin (Munich). 2001 Aug 15;96(8):485-8. German. PubMed PMID: 11560050.

[3] Almási R, Mágel F, Kósik G. [Cardiogenic shock and ventricular fibrillation induced by prajmalium and metoprolol poisoning]. Orv Hetil. 1996 Mar 31;137(13):695-700. Hungarian. PubMed PMID: 8649751.

[4] Szufladowicz E, Walczak F, Kozluk E, Jedynak Z, Buszman P, Lastowiecka E, Stepińska J. [Difficulties with pharmacologic treatment of a patient with atrioventricular nodal reentrant tachycardia]. Kardiol Pol. 1993 Oct;39(10):285-7. Polish. PubMed PMID: 8246357.

[5] Lenzen R, Stremmel W, Strohmeyer G. Antiarrhythmic drugs impair hepatic uptake and secretory function by different mechanisms in the isolated perfused rat liver. Biochim Biophys Acta. 1991 Aug 6;1074(3):406-12. PubMed PMID: 1888751.

6: Lenzen R, Gottesbüren H, Borchard F, Wienbeck M, Strohmeyer G. [Intrahepatic cholestasis and aplastic anemia following administration of prajmaline]. Klin Wochenschr. 1988 Mar 15;66(6):264-70. German. PubMed PMID: 2452916.7: Jaeger M. [How should we treat the Wolff-Parkinson-White syndrome]. Rev Med Suisse Romande. 1986 Oct;106(10):927-32. French. PubMed PMID: 3787033.8: Szatmáry L, Czakó E, Rényi-Vámos F, Bodor E, Rablóczky G. The acute effect of ajmaline on ventricular arrhythmia after cardiac surgery. Acta Med Hung. 1986;43(3):321-31. PubMed PMID: 3588171.9: Schmidt G, Goedel-Meinen L, Jahns G, Linné R, Schaudig U, Kein G, Baedeker W, Wirtzfeld A. Long term efficacy of class I antiarrhythmic agents and amiodarone in patients with malignant ventricular arrhythmias. Drugs. 1985 Mar;29 Suppl

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