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RU28362

NMR下載 COA and HPLC MSDS下載
names：
(8S,9S,10R,11S,13S,14S,17S)-11,17-dihydroxy-6,10,13-trimethyl-17-prop-1-ynyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-3-one
CAS號(hào)：
74915-64-3
MDL Number：
MF(分子式)： C23H28O3 MW(分子量)： 352.47
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	(8S,9S,10R,11S,13S,14S,17S)-11,17-dihydroxy-6,10,13-trimethyl-17-prop-1-ynyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-3-one
英文別名	RU28362; RU 28362; RU-28362.
CAS號(hào)	74915-64-3
Inchi	InChI=1S/C23H28O3/c1-5-8-23(26)10-7-17-16-11-14(2)18-12-15(24)6-9-21(18,3)20(16)19(25)13-22(17,23)4/h6,9,11-12,16-17,19-20,25-26H,7,10,13H2,1-4H3/t16-,17-,19-,20+,21-,22-,23-/m0/s1
InchiKey	UFZKDKHLKHEFGA-ZFTCBNFESA-N
分子式 Formula	C23H28O3
分子量 Molecular Weight	352.47
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	RU28362(CAS:74915-64-3):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	RU28362 is a glucocorticoid receptor agonist.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
安全防護(hù)
備注

[1]Francis AB, Pace TW, Ginsberg AB, Rubin BA, Spencer RL. Limited brain diffusion of the glucocorticoid receptor agonist RU28362 following i.c.v. administration: implications for i.c.v. drug delivery and glucocorticoid negative feedback in the hypothalamic-pituitary-adrenal axis. Neuroscience. 2006 Sep 1;141(3):1503-15. Epub 2006 Jun 27. PubMed PMID: 16806720.

[2]Ginsberg AB, Frank MG, Francis AB, Rubin BA, O'Connor KA, Spencer RL. Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary. J Neuroendocrinol. 2006 Feb;18(2):129-38. PubMed PMID: 16420282.

[3] Spencer RL, Moday HJ, Miller AH. Maintenance of Basal ACTH Levels by Corticosterone and RU28362, but not Aldosterone: Relationship to Available Type I and Type II Corticosteroid Receptor Levels in Brain and Pituitary. Stress. 1997 Oct;2(1):51-64. PubMed PMID: 9787255.

[4] Langley SC, Rickett GW, Hunt A, Kelly FJ, Postle AD, York DA. Effects of the glucocorticoid agonist, RU28362, and the antagonist RU486 on lung phosphatidylcholine and antioxidant enzyme development in the genetically obese Zucker rat. Biochem Pharmacol. 1993 Feb 9;45(3):543-51. PubMed PMID: 8442753.

[5] Woolley CS, Gould E, Sakai RR, Spencer RL, McEwen BS. Effects of aldosterone or RU28362 treatment on adrenalectomy-induced cell death in the dentate gyrus of the adult rat. Brain Res. 1991 Jul 19;554(1-2):312-5. PubMed PMID: 1933312.

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