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Rubradirin

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names：
A name could not be generated for this structure.
CAS號(hào)：
11031-38-2
MDL Number：
MF(分子式)： C48H46N4O20 MW(分子量)： 998.9
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	A name could not be generated for this structure.
英文別名	Rubradirin;
CAS號(hào)	11031-38-2
Inchi	InChI=1S/C48H46N4O20/c1-17-11-19(3)40(39(59)42(60)48(6)16-49-30-36(56)23-12-18(2)34(54)29(33(17)53)28(23)38(58)41(30)72-48)71-46(63)32-37(57)26(69-27-15-47(5,52(64)65)43(67-8)20(4)68-27)14-24(50-32)44(61)51-31-35(55)22-10-9-21(66-7)13-25(22)70-45(31)62/h9-14,19-20,27,39-40,43,49,54-55,57,59H,15-16H2,1-8H3,(H,51,61)/b17-11+/t19-,20-,27+,39-,40-,43+,47+,48+/m0/s1
InchiKey	GBZJIWQNTNUYGZ-ARBZVXFDSA-N
分子式 Formula	C48H46N4O20
分子量 Molecular Weight	998.9
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	Rubradirin(CAS:11031-38-2):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	Rubradirin is an antibiotic of complex chemical structure which is active vs. methicillin resistant staphylococci. It acts as a selective inhibitor of enzymatic peptide initiation.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
安全防護(hù)
備注

[1]Boll B, Heide L. A domain of RubC1 of rubradirin biosynthesis can functionally replace MbtH-like proteins in tyrosine adenylation. Chembiochem. 2013 Jan 2;14(1):43-4. doi: 10.1002/cbic.201200633. Epub 2012 Dec 6. PubMed PMID: 23225745.

[2]Hoeksema H, Lewis C, Mizsak SA, Shiley JA, Wait DR, Whaley HA, Zurenko GE. The isolation and characterization of rubradirin B. J Antibiot (Tokyo). 1978 Oct;31(10):945-8. PubMed PMID: 711617.

[3] Bannister B, Zapotocky BA. Protorubradirin, an antibiotic containing a C-nitroso-sugar fragment, is the true secondary metabolite produced by Streptomyces achromogenes var. rubradiris. Rubradirin, described earlier, is its photo-oxidation product. J Antibiot (Tokyo). 1992 Aug;45(8):1313-24. PubMed PMID: 1399853.

[4] Kim CG, Lamichhane J, Song KI, Nguyen VD, Kim DH, Jeong TS, Kang SH, Kim KW, Maharjan J, Hong YS, Kang JS, Yoo JC, Lee JJ, Oh TJ, Liou K, Sohng JK. Biosynthesis of rubradirin as an ansamycin antibiotic from Streptomyces achromogenes var. rubradiris NRRL3061. Arch Microbiol. 2008 May;189(5):463-73. Epub 2007 Dec 14. PubMed PMID: 18080113.

[5] Marshall VP, McWethy SJ, Sirotti JM, Cialdella JI. The effect of neutral resins on the fermentation production of rubradirin. J Ind Microbiol. 1990 Jul;5(5):283-7. PubMed PMID: 1366609.

6: Boll B, Hennig S, Xie C, Sohng JK, Heide L. Adenylate-forming enzymes of rubradirin biosynthesis: RubC1 is a bifunctional enzyme with aminocoumarin acyl ligase and tyrosine-activating domains. Chembiochem. 2011 May 2;12(7):1105-14. doi: 10.1002/cbic.201000778. Epub 2011 Mar 29. PubMed PMID: 21448870.7: Reusser F. Inhibition of ribosomal and RNA polymerase functions by rubradirin and its aglycone. J Antibiot (Tokyo). 1979 Nov;32(11):1186-92. PubMed PMID: 393685.8: Sohng JK, Oh TJ, Lee JJ, Kim CG. Identification of a gene cluster of biosynthetic genes of rubradirin substructures in S. achromogenes var. rubradiris NRRL3061. Mol Cells. 1997 Oct 31;7(5):674-81. PubMed PMID: 9387157.9: Reusser F. Rubradirin, a selective inhibitor of initiation factor dependent peptide-chain initiation. Biochemistry. 1973 Oct 23;12(22):4524-8. PubMed PMID: 4584327.10: MEYER CE. RUBRADIRIN, A NEW ANTIBIOTIC. II. ISOLATION AND CHARACTERIZATION. Antimicrob Agents Chemother (Bethesda). 1964;10:97-9. PubMed PMID: 14288039.1

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