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Trioxifene mesylate

NMR下載 COA and HPLC MSDS下載
names：
Ketone, 3,4-dihydro-2-(p-methoxyphenyl)-1-naphthyl-p-(2-(1-pyrrolidinyl)ethoxy)phenyl, methanesulfonate
CAS號(hào)：
68307-81-3
MDL Number：
MF(分子式)： C60H64N2O8S MW(分子量)： 973.24
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Ketone, 3,4-dihydro-2-(p-methoxyphenyl)-1-naphthyl-p-(2-(1-pyrrolidinyl)ethoxy)phenyl, methanesulfonate
英文別名	Trioxifene mesylate; LY133314; LY-133314; LY 133314;
CAS號(hào)	68307-81-3
Inchi	InChI=1S/C59H60N2O5.CH4O3S/c1-63-45-21-15-43(16-22-45)51-27-19-41-11-3-5-13-49(41)57(51)55-39-47(65-37-35-60-31-7-8-32-60)25-29-53(55)59(62)54-30-26-48(66-38-36-61-33-9-10-34-61)40-56(54)58-50-14-6-4-12-42(50)20-28-52(58)44-17-23-46(64-2)24-18-44;1-5(2,3)4/h3-6,11-18,21-26,29-30,39-40H,7-10,19-20,27-28,31-38H2,1-2H3;1H3,(H,2,3,4)
InchiKey	DHFAPIZDRMEMLX-UHFFFAOYSA-N
分子式 Formula	C60H64N2O8S
分子量 Molecular Weight	973.24
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Trioxifene mesylate(CAS:68307-81-3):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Trioxifene mesylate is an antiestrogen that inhibits growth hormone secretion.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
安全防護(hù)
備注

[1]Lee RW, Buzdar AU, Blumenschein GR, Hortobagyi GN. Trioxifene mesylate in the treatment of advanced breast cancer. Cancer. 1986 Jan 1;57(1):40-3. PubMed PMID: 3940620.

[2]Arafah B, Manni A, Pearson OH. Trioxifene mesylate (LY 133314): a new antiestrogen which inhibits growth hormone secretion in the rat. Eur J Cancer. 1980;Suppl 1:281-5. PubMed PMID: 7032941.

[3] Witte RS, Pruitt B, Tormey DC, Moss S, Rose DP, Falkson G, Carbone PP, Ramirez G, Falkson H, Pretorius FJ. A phase I/II investigation of trioxifene mesylate in advanced breast cancer. Clinical and endocrinologic effects. Cancer. 1986 Jan 1;57(1):34-9. PubMed PMID: 3079661.

[4] Neubauer BL, McNulty AM, Chedid M, Chen K, Goode RL, Johnson MA, Jones CD, Krishnan V, Lynch R, Osborne HE, Graff JR. The selective estrogen receptor modulator trioxifene (LY133314) inhibits metastasis and extends survival in the PAIII rat prostatic carcinoma model. Cancer Res. 2003 Sep 15;63(18):6056-62. PubMed PMID: 14522935.

[5] Black LJ, Jones CD, Goode RL. Differential interaction of antiestrogens with cytosol estrogen receptors. Mol Cell Endocrinol. 1981 Apr;22(1):95-103. PubMed PMID: 7239000.

6: Rose DP, Fischer AH, Jordan VC. Activity of the antioestrogen trioxifene against N-Nitrosomethylurea-induced rat mammary carcinomas. Eur J Cancer Clin Oncol. 1981 Aug;17(8):893-8. PubMed PMID: 7198978.7: Black LJ, Goode RL. Uterine bioassay of tamoxifen, trioxifene and a new estrogen antagonist (LY117018) in rats and mice. Life Sci. 1980 Apr 28;26(17):1453-8. PubMed PMID: 7382727.8: Wakeling AE, Valcaccia B. Antioestrogenic and antitumour activities of a series of non-steroidal antioestrogens. J Endocrinol. 1983 Dec;99(3):455-64. PubMed PMID: 6644236.9: Castracane VD, Kuehl TJ, Goldzieher JW. The effect of estrogen antagonism on progesterone production in early pregnancy in the baboon (Papio cynocephalus). Am J Obstet Gynecol. 1983 Mar 15;145(6):725-9. PubMed PMID: 6829661.10: Jones CD, Blaszczak LC, Goettel ME, Suarez T, Crowell TA, Mabry TE, Ruenitz PC, Srivatsan V. Antiestrogens. 3. Estrogen receptor affinities and antiproliferative effects in MCF-7 cells of phenolic analogues of trioxifene, [3,4-dihydro-2-(4- methoxyphenyl)-1-naphthalenyl][4-[2-(1-pyrrolidinyl)ethoxy]- phenyl]methanone. J Med Chem. 1992 Mar 6;35(5):931-8. PubMed PMID: 1548683.1

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