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Vinthionine

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names：
S-vinyl-L-homocysteine
CAS號：
70858-14-9
MDL Number：
MF(分子式)： C6H11NO2S MW(分子量)： 161.21
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	S-vinyl-L-homocysteine
英文別名	Vinthionine; L-Vinthionine; S-Ethenyl-L-homocysteine;
CAS號	70858-14-9
Inchi	InChI=1S/C6H11NO2S/c1-2-10-4-3-5(7)6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-/m0/s1
InchiKey	ZDASADFVRGVYFK-YFKPBYRVSA-N
分子式 Formula	C6H11NO2S
分子量 Molecular Weight	161.21
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Vinthionine(CAS:70858-14-9):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Vinthionine binds covalently to rat liver DNA, RNA and protein in vivo, but not in vitro. This amino acid is directly mutagenic in Salmonella typhimurium TA100 and TA1535; the mechanism of its metabolic activation in vivo in bacteria and liver is under study.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
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[1]Catcott KC, Yan J, Qu W, Wysocki VH, Zhou ZS. Identifying Unknown Enzyme-Substrate Pairs from the Cellular Milieu with Native Mass Spectrometry. Chembiochem. 2017 Apr 4;18(7):613-617. doi: 10.1002/cbic.201600634. Epub 2017 Mar 14. PubMed PMID: 28140508.

[2]Vaughan MD, Su Z, Daub E, Honek JF. Intriguing cellular processing of a fluorinated amino acid during protein biosynthesis in Escherichia coli. Org Biomol Chem. 2016 Sep 26;14(38):8942-8946. PubMed PMID: 27722405.

[3] Qu W, Catcott KC, Zhang K, Liu S, Guo JJ, Ma J, Pablo M, Glick J, Xiu Y, Kenton N, Ma X, Duclos RI Jr, Zhou ZS. Capturing Unknown Substrates via in Situ Formation of Tightly Bound Bisubstrate Adducts: S-Adenosyl-vinthionine as a Functional Probe for AdoMet-Dependent Methyltransferases. J Am Chem Soc. 2016 Mar 9;138(9):2877-80. doi: 10.1021/jacs.5b05950. Epub 2016 Feb 29. PubMed PMID: 26901520.

[4] Sohn YW, Lee GH, Liem A, Miller JA. Activation of H-ras oncogenes in male B6C3F1 mouse liver tumors induced by vinthionine or 2-chloroethyl-methyl sulfide. Carcinogenesis. 1996 Jun;17(6):1361-4. PubMed PMID: 8681456.

[5] Kim HJ, Balcezak TJ, Nathin SJ, McMullen HF, Hansen DE. The use of a spectrophotometric assay to study the interaction of S-adenosylmethionine synthetase with methionine analogues. Anal Biochem. 1992 Nov 15;207(1):68-72. PubMed PMID: 1489102.

6: Koechel DA, Krejci ME, Ridgewell RE. The acute effects of S-(1,2-dichlorovinyl)-L-cysteine and related chemicals on renal function and ultrastructure in the pentobarbital-anesthetized dog: structure-activity relationships, biotransformation, and unique site-specific nephrotoxicity. Fundam Appl Toxicol. 1991 Jul;17(1):17-33. PubMed PMID: 1916074.7: Leopold WR, Miller JA, Miller EC. Comparison of some carcinogenic, mutagenic, and biochemical properties of S-vinylhomocysteine and ethionine. Cancer Res. 1982 Nov;42(11):4364-74. PubMed PMID: 6290034.

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