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Withanolide B

NMR下載 COA and HPLC MSDS下載
names：
(5alpha,6alpha,7alpha,22R)-5-Hydroxy-6,722,26-diepoxyergosta-2,24-diene-1,26-dione
CAS號：
56973-41-2
MDL Number：
MF(分子式)： C28H38O5 MW(分子量)： 454.607
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	(5alpha,6alpha,7alpha,22R)-5-Hydroxy-6,722,26-diepoxyergosta-2,24-diene-1,26-dione
英文別名	Withanolide B
CAS號	56973-41-2
Inchi	InChI=1S/C28H38O5/c1-14-13-20(32-25(30)15(14)2)16(3)17-8-9-18-22-19(10-12-26(17,18)4)27(5)21(29)7-6-11-28(27,31)24-23(22)33-24/h6-7,16-20,22-24,31H,8-13H2,1-5H3/t16-,17+,18-,19-,20+,22-,23+,24+,26+,27-,28-/m0/s1
InchiKey	ZTEVDTFJUUJBLP-HGSBMKTESA-N
分子式 Formula	C28H38O5
分子量 Molecular Weight	454.607
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Withanolide B(CAS:56973-41-2):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Withanolide B is a withanolide that has been found in W. somnifera. Unlike withanolide A, it does not increase glucose uptake in L6 myotubes. In in silico docking studies, withanolide B was identified as a neuronal nitric oxide synthase (nNOS) inhibitor that also inhibited inducible NOS (iNOS) and endothelial NOS and as a ligand for the PARP1 catalytic domain.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
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[1]Ben Bakrim W, El Bouzidi L, Nuzillard JM, Cretton S, Saraux N, Monteillier A, Christen P, Cuendet M, Bekkouche K. Bioactive metabolites from the leaves of Withania adpressa. Pharm Biol. 2018 Dec;56(1):505-510. doi: 10.1080/13880209.2018.149978[1]PubMed PMID: 30451050; PubMed Central PMCID: PMC6249549.

[2]Dubey S, Kallubai M, Sarkar A, Subramanyam R. Elucidating the active interaction mechanism of phytochemicals withanolide and withanoside derivatives with human serum albumin. PLoS One. 2018 Nov 7;13(11):e0200053. doi: 10.1371/journal.pone.0200053. eCollection 2018. PubMed PMID: 30403672; PubMed Central PMCID: PMC6221254.

[3] Hussain H, Csuk R, Green IR, Ur Rehman N, Abbas G, Hussain W. Journey Describing the Cytotoxic Potential of Withanolides: A Patent Review. Recent Pat Anticancer Drug Discov. 2018;13(4):411-421. doi: 10.2174/1574892813666180808154928. Review. PubMed PMID: 30091418.

[4] Mishra A, Singh SP, Mahfooz S, Bhattacharya A, Mishra N, Shirke PA, Nautiyal CS. Bacterial endophytes modulates the withanolide biosynthetic pathway and physiological performance in Withania somnifera under biotic stress. Microbiol Res. 2018 Jul - Aug;212-21

[5]17-28. doi: 10.1016/j.micres.2018.04.006. Epub 2018 Apr 22. PubMed PMID: 29853165.

5: Yang L, Meng X, Kuang H. Comparisons of the pharmacokinetic and tissue distribution profiles of withanolide B after intragastric administration of the effective part of Datura metel L. in normal and psoriasis guinea pigs. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Apr 15;108

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