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Amifostine trihydrate

NMR下載 COA and HPLC MSDS下載
names：
S-(2-((3-aminopropyl)amino)ethyl) O,O-dihydrogen phosphorothioate trihydrate
CAS號：
112901-68-5
MDL Number：
MF(分子式)： C5H21N2O6PS MW(分子量)： 268.26
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Amifostine trihydrate
英文別名	WR2721; WR-2721; WR 2721; YM08310; YM-08310; YM 08310; Aminopropylaminoethylthiophosphoric Acid; ethiofos; gammaphos. US brand name Ethyol. Abbreviation APAETP.
CAS號	112901-68-5
Inchi	InChI=1S/C5H15N2O3PS.3H2O/c6-2-1-3-7-4-5-12-11(8,9)10;;;/h7H,1-6H2,(H2,8,9,10);3*1H2
InchiKey	TXQPXJKRNHJWAX-UHFFFAOYSA-N
分子式 Formula	C5H21N2O6PS
分子量 Molecular Weight	268.26
溶解度Solubility
性狀	white solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Amifostine trihydrate(CAS:112901-68-5 ):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Amifostine is a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護(hù)
備注

[1]Duval M, Daniel SJ. Meta-analysis of the efficacy of amifostine in the prevention of cisplatin ototoxicity. J Otolaryngol Head Neck Surg. 2012 Oct;41(5):309-15. Review. PubMed PMID: 23092832.

[2]Nicolatou-Galitis O, Sarri T, Bowen J, Di Palma M, Kouloulias VE, Niscola P, Riesenbeck D, Stokman M, Tissing W, Yeoh E, Elad S, Lalla RV; Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). Systematic review of amifostine for the management of oral mucositis in cancer patients. Support Care Cancer. 2013 Jan;21(1):357-64. doi: 10.1007/s00520-012-1613-6. Epub 2012 Oct 3. Review. PubMed PMID: 23052919.

[3] Ma C, Xie J, Jiang Z, Wang G, Zuo S. Does amifostine have radioprotective effects on salivary glands in high-dose radioactive iodine-treated differentiated thyroid cancer. Eur J Nucl Med Mol Imaging. 2010 Aug;37(9):1778-85. doi: 10.1007/s00259-009-1368-6. Epub 2010 Feb 4. Review. PubMed PMID: 20130857.

[4] Dang YH, Li W, Yang B, Zhu HL, Huang Y. [Mechanism and problem of amifostine in treating myelodysplastic syndromes]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Dec;17(6):1597-601. Review. Chinese. PubMed PMID: 20030955.

[5] Ma C, Xie J, Chen Q, Wang G, Zuo S. Amifostine for salivary glands in high-dose radioactive iodine treated differentiated thyroid cancer. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007956. doi: 10.1002/14651858.CD007956.pub2. Review. PubMed PMID: 19821441.

6: Marcu LG. The role of amifostine in the treatment of head and neck cancer with cisplatin-radiotherapy. Eur J Cancer Care (Engl). 2009 Mar;18(2):116-23. doi: 10.1111/j.1365-2354.2008.01032.x. Review. PubMed PMID: 19267726.7: Mell LK, Movsas B. Pharmacologic normal tissue protection in clinical radiation oncology: focus on amifostine. Expert Opin Drug Metab Toxicol. 2008 Oct;4(10):1341-50. doi: 10.1517/17425255.4.10.1341 . Review. PubMed PMID: 18798703.8: Praetorius NP, Mandal TK. Alternate delivery route for amifostine as a radio-/chemo-protecting agent. J Pharm Pharmacol. 2008 Jul;60(7):809-15. doi: 10.1211/jpp.60.7.0001. Review. PubMed PMID: 18549666.9: Kouloulias VE, Kouvaris JR. Cytoprotective efficacy of amifostine against radiation- induced rectal toxicity: objective and subjective grading scales for radiomucositis. Molecules. 2008 Apr 18;13(4):892-903. Review. PubMed PMID: 18463591.10: Kouvaris JR, Kouloulias VE, Vlahos LJ. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47. Review. PubMed PMID: 17602063.

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