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SC 4453

NMR下載 COA and HPLC MSDS下載
names：
SC 4453
CAS號：
59712-21-9
MDL Number：
MF(分子式)： C41H64N2O12 MW(分子量)： 776.96
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	(2S,3R,4S,6S)-6-(((2S,3S,4S,6R)-6-(((2R,3S,4S,6R)-6-(((3R,5R,8R,9R,10S,12S,13S,14S,17S)-12,14-dihydroxy-10,13-dimethyl-17-(pyridazin-4-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3,4-diol
英文別名	SC 4453; SC-4453; SC4453;
CAS號	59712-21-9
Inchi	InChI=1S/C41H64N2O12/c1-20-36(48)29(44)16-34(50-20)54-38-22(3)52-35(18-31(38)46)55-37-21(2)51-33(17-30(37)45)53-25-8-11-39(4)24(14-25)6-7-27-28(39)15-32(47)40(5)26(9-12-41(27,40)49)23-10-13-42-43-19-23/h10,13,19-22,24-38,44-49H,6-9,11-12,14-18H2,1-5H3/t20-,21+,22-,24+,25+,26-,27+,28+,29-,30-,31-,32-,33-,34-,35+,36-,37+,38+,39-,40-,41-/m0/s1
InchiKey	OUDJBXKBCFRTRI-FKLSQBIHSA-N
分子式 Formula	C41H64N2O12
分子量 Molecular Weight	776.96
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	SC 4453(CAS:59712-21-9):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	SC 4453 is a digoxin analog and a cardiac glycoside derivative.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Randimbivololona F. Distribution of SC-4453, a new semi-synthetic derivative of digoxin, following an infusion preceded by an i.v. loading dose in the guinea-pig. Binding to plasma proteins. Eur J Drug Metab Pharmacokinet. 1988 Jan-Mar;13(1):19-22. PubMed PMID: 3396609.

[2]Randimbivololona F, Lesne M. Intestinal absorption of SC4453 in the guinea-pig. Arch Int Pharmacodyn Ther. 1982 Dec;260(2):296-8. PubMed PMID: 7165435.

[3] Randimbivololona F, Lesne M. Importance of the urinary excretion in the total elimination of SC4453 in the guinea-pig. J Pharmacol. 1984 Apr-Jun;15(2):199-208. PubMed PMID: 6738077.

[4] Gupta RS, Chopra A. Cross-resistance and biochemical studies with two classes of HeLa cell mutants resistant to cardiac glycosides. The unusual behavior of cardenolide SC4453. J Biol Chem. 1985 Jun 10;260(11):6843-50. PubMed PMID: 2987235.

[5] Chopra A, Dudani AK, Gupta RS. Cross-resistance and biochemical characteristics of second-step mutants of HeLa cells resistant to cardiac glycosides. Biochem Cell Biol. 1990 May;68(5):852-7. PubMed PMID: 2169261.

6: Randimbivololona F, Lesne M. Metabolism and excretion in bile of SC4453, a new semi-synthetic derivative of digoxin following an i.v. bolus injection in the guinea-pig. J Pharmacol. 1984 Jan-Mar;15(1):53-64. PubMed PMID: 6717027.7: Gupta RS, Chopra A, Trott AB. Development of a specific assay for cardiac glycoside-like compounds based on cross-resistance of human cell mutants. Biochem Pharmacol. 1989 Jul 1;38(13):2159-68. PubMed PMID: 2735954.8: Randimbivololona F, Lesne M. Comparison of the pharmacokinetic parameters of digoxin and SC4453 a digoxin analogue, following a single bolus i.v. dose and following an infusion preceeded by an i.v. loading dose in the guinea-pig. J Pharmacol. 1983 Jan-Mar;14(1):9-17. PubMed PMID: 6834854.9: Gupta RS, Chopra A. Human cell mutants affected in the interaction of the 12 beta-OH group of cardiac glycosides with the digitalis receptor. Biochem Pharmacol. 1987 Nov 15;36(22):3829-33. PubMed PMID: 2825704.10: Chopra A, Gupta RS. Biochemical and cross-resistance studies with HeLa cell mutants resistant to cardiac glycoside SC4453. Regulation of the resistant form of Na+/K+-ATPase in the mutant cells. J Biol Chem. 1986 Feb 15;261(5):2034-40. PubMed PMID: 3003091.

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