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4-戊炔酸琥珀亞胺酯

NMR下載 COA and HPLC MSDS下載
names：
Propargyl-C1-NHS ester
CAS號：
132178-37-1
MDL Number： MFCD22577791
MF(分子式)： C9H9NO4 MW(分子量)： 195.17
EINECS: Reaxys Number:
Pubchem ID:57339402 Brand:BIOFOUNT

4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)是一種不可降解的 linker，Propargyl-C1-NHS ester可用于合成抗體偶聯(lián)藥物 (ADC) 。

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數(shù)量	總計 (￥)
YZM001020-500mg	500mg	95%	￥ 8560.00	￥ 8560.00		1-3days	- +	￥ 0.00
YZM001020-100mg	100mg	95%	￥ 2800.00	￥ 2800.00		1-3days	- +	￥ 0.00

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中文別名	4-戊炔酸琥珀亞胺酯(132178-37-1);
英文別名	Propargyl-C1-NHS ester(132178-37-1);2,5-dioxopyrrolidin-1-yl pent-4-ynoate;4-Pentynoic acid NHS ester;Propargyl-C1-NHS ester;PROPARGYL-C1-NHS ESTER;4-Pentynoic acid succinimidyl ester;
CAS號	132178-37-1
Inchi	InChI=1S/C9H9NO4/c1-2-3-4-9(13)14-10-7(11)5-6-8(10)12/h1H,3-6H2
InchiKey	VLQOCPXVAZTWQR-UHFFFAOYSA-N
分子式 Formula	C9H9NO4
分子量 Molecular Weight	195.17
溶解度Solubility
性狀	Solid
儲藏條件 Storage conditions	請根據(jù)產(chǎn)品建議的存儲條件進行存儲,Please store the product under the recommended condition sin the description.

4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags:32178-37-1試劑,32178-37-1雜質(zhì),32178-37-1合成,32178-37-1密度,32178-37-1溶解度,32178-37-1旋光度,32178-37-1閃點,32178-37-1熔點,32178-37-1購買,32178-37-1MSDS,

產(chǎn)品說明	4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)是一種不可降解的 linker,可用于合成抗體偶聯(lián)藥物 (ADC)
Introduction	4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)is a nonclaevable linker for antibodyrugonjugation (ADC).
Application1
Application2
Application3

4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)藥理學(xué)：

4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)是一種不可降解的 linker，Propargyl-C1-NHS ester可用于合成抗體偶聯(lián)藥物 (ADC) 。

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

Bastian et al. Selective transformations of complex molecules are enabled by aptameric protective groups. Nature Chemistry, doi: 10.1038/nchem.1402, published online 22 July 2012 http://www.nature.com

Design and Modular Construction of a Polymeric Nanoparticle for Targeted Atherosclerosis Positron Emission Tomography Imaging: A Story of 25% 64Cu-CANF-Comb Pharmaceutical Research 2016 27286872

Fabrication of device with poly(N-isopropylacrylamide)-b-ssDNA copolymer brush for resistivity study Journal of Nanobiotechnology 2017 28982368

Molecular Targeted Viral Nanoparticles as Tools for Imaging Cancer Virus Hybrids as Nanomaterials 2014 24243252

Design and Modular Construction of a Polymeric Nanoparticle for Targeted Atherosclerosis Positron Emission Tomography Imaging: A Story of 25% 64Cu-CANF-Comb Pharmaceutical Research 2016 27286872

4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)參考文獻：

1、Selective transformations of complex molecules are enabled by aptameric protective groups
Andreas A. Bastian, Alessio Marcozzi & Andreas Herrmann

Abstract Emerging trends in drug discovery are prompting a renewed interest in natural products as a source of chemical diversity and lead structures. However, owing to the structural complexity of many natural compounds, the synthesis of derivatives is not easily realized. Here, we demonstrate a conceptually new approach using oligonucleotides as aptameric protective groups. These block several functionalities by non-covalent interactions in a complex molecule and enable the highly chemo- and regioselective derivatization (>99%) of natural antibiotics in a single synthetic step with excellent conversions of up to 83%. This technique reveals an important structure–activity relationship in neamine-based antibiotics and should help both to accelerate the discovery of new biologically active structures and to avoid potentially costly and cumbersome synthetic routes.

2、Preparation of Peptide and Other Biomolecular Conjugates Through Chemoselective Ligations
Mathieu GalibertOlivier RenaudetDidier BoturynPascal Dumy

Abstract The synthesis of molecular conjugates through chemoselective ligations represents a very convenient strategy to prepare complex macromolecules with diverse functional elements. Herein, we describe chemical methods based on the preparation of chemoselectively addressable peptides allowing successive oxime ligations and/or alkyne–azide cycloaddition (“click”) reactions of various biomolecules. This modular synthetic approach can be applied to a broad range of purposes.

3、Fabrication of device with poly(N-isopropylacrylamide)-b-ssDNA copolymer brush for resistivity study
Yi-Zu Liu, May-Show Chen, Chih-Chia Cheng, Shih-Hsun Chen & Jem-Kun Chen

Abstract In this study, we grafted bromo-terminated poly(N-isopropylacrylamide) (PNIPAAm) brushes onto thin gold films deposited on silicon, and then reacted with NaN3 to produce azido-terminated PNIPAAm brushes. A probe sequence of single-stranded DNA (ssDNA) with a 4-pentynoic acid succinimidyl ester unit was grafted onto the azido-terminated PNIPAAm brushes through a click reaction, resulting in the formation of block copolymer brushes. The PNIPAAm-b-ssDNA copolymer brushes formed supramolecular complexes stabilized by bio-multiple hydrogen bonds (BMHBs), which enhanced the proton transfer and thereby decreased the resistivity of the structures. In addition, the optimal operation window for DNA detection ranges from 0 to 0.2 M of NaCl concentration. Therefore, the specimens were prepared in the PBS solution at 150 mM NaCl concentration for target hybridization. The supramolecular complex state of the PNIPAAm-b-ssDNA copolymer brushes transformed into the phase-separated state after the hybridization with 0.5 ng/µL of its target DNA sequence owing to the competition between BMHBs and complementary hydrogen bonds. This phase transformation of the PNIPAAm and probe segments inhibited the proton transfer and significantly increased the resistivity at 25 °C. Moreover, there were no significant changes in the resistivity of the copolymer brushes after hybridization with the target sequence at 45 °C. These results indicated that the phase-separated state of the PNIPAAm-b-ssDNA copolymer brushes, which was generally occurred above the LCST, can be substantially generated after hybridization with its target DNA sequence. By performing the controlled experiments, in the same manner, using another sequence with lengths similar to that of the target sequence without complementarity. In addition, the sequences featuring various degrees of complementarity were exploited to verify the phase separation behavior inside the PNIPAAm-b-ssDNA copolymer thin film.

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