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Apidaecin IB

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names：
Apidaecin IB
CAS號：
123276-94-8
MDL Number：
MF(分子式)： C95H150N32O23 MW(分子量)： 2108.41
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

Apidaecin IB(123276-94-8)是一種昆蟲抗菌肽，Apidaecin IB抑制大腸桿菌（大腸桿菌 ML35，O18K1H7和ATCC 25922）的最小最小濃度為8μM。

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數(shù)量	總計 (￥)
YZM000396-1mg	1mg	>97%	￥ 1365.00	￥ 1365.00		Backorder	- +	￥ 0.00

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中文別名	Apidaecin IB(123276-94-8);
英文別名	Apidaecin IB(123276-94-8);GNNRPVYIPQPRPPHPRL;
CAS號	123276-94-8
Inchi	No data available
InchiKey	No data available
分子式 Formula	C95H150N32O23
分子量 Molecular Weight	2108.41
溶解度Solubility
性狀	Solid
儲藏條件 Storage conditions	請根據(jù)產(chǎn)品建議的存儲條件進行存儲,Please store the product under the recommended condition sin the description.

Apidaecin IB(123276-94-8)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產(chǎn)品說明	Apidaecin IB(123276-94-8)是一種有效的昆蟲抗菌肽,Apidaecin IB抑制大腸桿菌三種菌株的最小濃度均是 8 μM。
Introduction	Apidaecin IB(123276-94-8)is a insect antimicrobial peptide, with minimum inhibitory concentration (MIC) values of 8 μM forE. coli(ML35, O18K1H7 and ATCC 25922).
Application1
Application2
Application3

Apidaecin IB(123276-94-8)藥理學：

Apidaecin IB(123276-94-8)是一種昆蟲抗菌肽，Apidaecin IB抑制大腸桿菌（大腸桿菌 ML35，O18K1H7和ATCC 25922）的最小最小濃度為8μM。

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

Gobbo M, et al. Substitution of the arginine/leucine residues in apidaecin Ib with peptoid residues: effect on antimicrobial activity, cellular uptake, and proteolytic degradation. J Med Chem. 2009 Au

Apidaecin IB(123276-94-8)參考文獻：

1、Substitution of the arginine/leucine residues in apidaecin Ib with peptoid residues: effect on antimicrobial activity, cellular uptake, and proteolytic degradation
Marina Gobbo 1, Monica Benincasa, Giulio Bertoloni, Barbara Biondi, Ryan Dosselli, Emanuele Papini, Elena Reddi, Raniero Rocchi, Regina Tavano, Renato Gennaro

Abstract Several aspects of the mechanism of action of Pro-rich antimicrobial peptides, together with their low toxicity in mammalian cells, make them good candidates for the development of new antibiotic agents. We investigated the effect induced in the insect antimicrobial peptide apidaecin Ib by the replacement of a single arginine/leucine residue with a N-substituted glycine. The resulting peptoid-peptide hybrids are more resistant to proteolysis and devoid of any significant cytotoxic activity, but moving the [NArg]residue from the N- to the C-terminal end of the molecule progressively reduces the antibacterial activity. Cell uptake experiments in E. coli cells suggest that the loss of antibacterial activity of [NArg(17)]apidaecin is a consequence of its inability to translocate into bacterial cells. Conversely, apidaecin and its peptoid-peptide hybrids are able to cross the plasma membrane in eukaryotic cells and to diffuse in the cytosol, although their translocating ability is far less effective than that of other known cell permeant peptides.

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