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紫菫定酚

NMR下載 COA and HPLC MSDS下載
names：
Corydine
CAS號：
476-69-7
MDL Number： MFCD00076020
MF(分子式)： C20H23NO4 MW(分子量)： 341.4
EINECS:No data available Reaxys Number:No data available
Pubchem ID:10153 Brand:BIOFOUNT

紫菫定酚(476-69-7,Corydine)是一種天然存在的生物堿，可從巴豆echinocarpus 葉子中提取.Corydine有效抑制逆轉(zhuǎn)錄酶（逆轉(zhuǎn)錄酶，RT）活性，IC₅₀為356.8μg/mL。Corydinez在體外具有抗HIV潛力，濃度為450μg/ mL時抑制40％的HIV-1逆轉(zhuǎn)錄酶活性。

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數(shù)量	總計 (￥)
YZM000679-5mg	5mg		￥ 4080.00	￥ 4080.00		Backorder	- +	￥ 0.00
YZM000679-1mg	1mg	>97%	￥ 1306.50	￥ 1306.50		2-3天	- +	￥ 0.00

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中文別名	紫菫定酚(476-69-7);紫定酚;(+)-延胡索堿;
英文別名	Corydine(476-69-7);Glaucentrin; Glaucentrine; d-Corydine; corydine hydrochloride;corydine, (R)-isomer;
CAS號	476-69-7
Inchi	InChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)19(22)18-16(12)13(21)9-11-5-6-14(23-2)20(25-4)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1
InchiKey	IDQUPXZJURZAGF-ZDUSSCGKSA-N
分子式 Formula	C20H23NO4
分子量 Molecular Weight	341.4
溶解度Solubility
性狀	Solid
儲藏條件 Storage conditions	請根據(jù)產(chǎn)品建議的存儲條件進行存儲,Please store the product under the recommended condition sin the description.

紫菫定酚(476-69-7,Corydine)毒理性質(zhì)：

生物	測試類型	路線	劑量	影響	參考
mouse	LD50	subcutaneous	115 mg/kg (115 mg/kg)		Farmakologiya i Toksikologiya, 31(44), 1968 [PMID:5691957]

紫菫定酚(476-69-7,Corydine)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產(chǎn)品說明	紫菫定酚(476-69-7,Corydine)是一種有效的天然存在的生物堿，可從Croton echinocarpus葉子中提取
Introduction	紫菫定酚(476-69-7,Corydine) is a naturally occurring alkaloid which can be extracted from plants such asCroton echinocarpusleaves.
Application1	紫菫定酚具有抑菌，清熱解毒，殺蟲止癢的作用。Corydine是一種具有抗菌和抗腫瘤活性的生物堿。
Application2	Corydine is efficient on inhibitingreverse transcriptase activity with an IC50of356.8μg/mL.
Application3	Corydine displays significant in vitro antiIVpotential, inhibiting 40% of ?the HIV reverse transcriptase enzyme activity at a concentration of ?450 μg/mL of ?Corydine.

紫菫定酚(476-69-7,Corydine)藥理學(xué)：

※Corydine是一種天然存在的生物堿，可從巴豆echinocarpus 葉子中提取.Corydine有效抑制逆轉(zhuǎn)錄酶（逆轉(zhuǎn)錄酶，RT）活性，IC₅₀為356.8μg/mL。Corydinez在體外具有抗HIV潛力，濃度為450μg/ mL時抑制40％的HIV-1逆轉(zhuǎn)錄酶活性。

※紫菫定酚具有抑菌，清熱解毒，殺蟲止癢的作用。

※Corydine是一種具有抗菌和抗腫瘤活性的生物堿。

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

N.Ravanelli, et al. Alkaloids from Croton echinocarpus Baill.: Anti-HIV potential. South African Journal of Botany. 2016 Jan, 102: 153-156

Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine PMID 2290126; Journal of pharmacobio-dynamics 1990 Jul; 13(7):426-31 Name

Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigg. & Kort PMID 17574358; Journal of ethnopharmacology 2007 Aug; 113(1):179-82 Name matches: acetylcholine

Stereochemical preferences for curarimimetic neuromuscular junction blockade I: enantiomeric monoquaternary amines as probes PMID 124343; Journal of pharmaceutical sciences 1975 Jan; 64(1):53-62 Name

Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists PMID 32796875; Scientific reports 2020 Aug; 10(1):13804 Name matches: arre

紫菫定酚(476-69-7,Corydine)參考文獻：

1.[Alkaloids from Dactylicapnos scandens Hutch].
Wang F1, Hu X, Chen H, Ma J, Wang J, Hou A. Zhongguo Zhong Yao Za Zhi. 2009 Aug;34(16):2057-9.

OBJECTIVE: To investigate the alkaloids in the roots of Dactylicapnos scanden (D. Don) Hutch.

2.Comprehensive separation and analysis of alkaloids from Stephania yunnanensis by counter-current chromatography coupled with liquid chromatography tandem mass spectrometry analysis.
Dai X1, Hu R, Sun C, Pan Y. J Chromatogr A. 2012 Feb 24;1226:18-23. doi: 10.1016/j.chroma.2011.10.022. Epub 2011 Oct 14.

The polar compounds such as alkaloid compounds are important bioactive components in traditional Chinese medicines. In present study, a comprehensive method for separation and analysis of polar compounds from the polar fraction of traditional Chinese medicine Stephania yunnanensis was established. Both the major components and minor components were analyzed by counter-current chromatography combined with liquid chromatography tandem mass spectrometry (LC-MS(n)). From 50 mg polar fraction of crude extract, 15.2mg corydine and 4.8 mg stepharine with purities over 90% were successfully separated via a polar solvent system n-butanol: methanol: water (4:1:5, v/v) with 10 mM NaOH as an additive in the lower phase, in one step operation. Their structures were further identified by 1H NMR and FTICR-MS. Besides, three minor components were identified by HPLC-MS(n) based on the fragmentation behavior of the purified compounds.

3.Aporphine alkaloids from the roots of Stephania viridiflavens.
Zhang M1, Liang G, Yu J, Pan W. Nat Prod Res. 2010 Aug;24(13):1243-7. doi: 10.1080/14786410903125393.

Further investigation on the phytochemistry of the medicinal plant Stephania viridiflavens led to the isolation of a new naturally occurring aporphine alkaloid, (+)-6R, 6aS-isocorydine N(beta)-oxide (1), together with three known aporphine alkaloids: (+)-6R, 6aS-corydine N(beta)-oxide (2), (+)-N-methyl-laurotetanine (3) and (+)-stepharine (4). The structure and stereochemistry of 1 were determined on the basis of spectroscopic methods and confirmed by synthesis. Alkaloids 2-4 were isolated for the first time from this species.

4.Preparative separation of isoquinoline alkaloids from Stephania yunnanensis by pH-zone-refining counter-current chromatography.
Hu R1, Dai X, Lu Y, Pan Y. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jul 1;878(21):1881-4. doi: 10.1016/j.jchromb.2010.05.005. Epub 2010 May 9.

In this paper, five isoquinoline alkaloids were successfully separated from a crude extract of Stephania yunnanensis using pH-zone-refining counter-current chromatography in single-step. With a two-phase solvent system composed of methyl-tert-butyl ether (MtBE)-acetonitrile-water (2:2:3, v/v) where triethylamine (10 mM) was added to the upper organic phase as a retainer and hydrochloric acid (5 mM) to the aqueous mobile phase as an eluter. From 1.4 g crude extract, 68.7 mg isocorydine, 78.2 mg corydine, 583.4 mg tetrahydropalmatine, 36.3 mg N-methylasimilobine, and 47.3 mg anonaine were separated with purities over 90%. Their structures were identified by (1)H NMR, (13)C NMR, ESI-MS data.

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